A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12 |
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| Authors: | Andrews Peter W. Knowles Barbara B. Goodfellow Peter N. |
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| Affiliation: | (1) The Wistar Institute, 36 Street at Spruce, 19104 Philadelphia, Pennsylvania;(2) Imperial Cancer Research Fund, Lincoln's Inn Fields, WC2A 3PX London, UK |
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| Abstract: | A murine monoclonal antibody 602-29, subclass IgG1, that recognizes an antigenic determinant expressed by most human cells is described. Immunoprecipitation and sodium dodecyl sulfate-gel electrophoresis analysis indicate that the antigenic determinant is carried by a protein with an apparent molecular weight of 21,000. The antigen is expressed by human-mouse somatic cell hybrids, and analysis of segregants that have lost human chromosomes indicates that the gene controlling expression of the 602-29 antigen is on chromosome 12. |
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