96例急性脑梗死患者血清超敏C反应蛋白的检测及相关性研究

目的探讨急性脑梗死患者治疗前后血清超敏C反应蛋白(hs-CRP)水平及其与临床神经功能缺损程度评分的相关性。方法96例急性脑梗死患者中轻型35例、中型36例、重型25例,均采空腹静脉血3 mL,分离血清,采用胶乳增强免疫比浊法对hs-CRP进行检测;选取35例健康体检者为对照组,方法同上。结果急性脑梗死患者治疗前hs-CRP含量明显高于正常对照组(P<0.01),治疗2周后与正常对照组差异无统计学意义(P>0.05);脑梗死各组间血清hs-CRP含量两两比较差异均有统计学意义(P<0.01),脑梗死患者hs-CRP含量与其临床神经功能缺损程度评分呈正相关。结论hs-CRP作为一种炎症标志物,在脑梗死的形成和进展中起关键性的作用,能反映脑梗死病情的严重程度,对于急性脑梗死的诊断、病情监测和预后判定具有一定价值。

Correlative Study on Serum Levels of High-sensitivity C-reactive Protein in 96 Patients with Acute Cerebral Infarction

Objective To investigate the expression of high-sensitivity C-reactive protein （hs-CRP） in patients with acute cerebral infarction before or after treatment and the correlation between hs-CRP and clinical neurologic impairment score. Methods 96 patients with acute cerebral infarction and 35 healthy were recruited. Of the 96 cases,35 were evaluated as mild situation,36 were moderate and 25 were severe. 3 mL of fasting venous blood were taken for every, sample, hs-CRP was detected by using latex enhanced immunoturbidimetry. Results hs-CRP in patients with acute cerebral infarction before treatment were significantly higher than that in the normal control group （P 〈 0.01 ）. After two weeks treatment, there were no significant difference （ P 〉 0.05 ） between patients and the normal control group. There were significant （ P 〈 0.01 ） difference among mild,moderate and severe group, hs-CRP in patients was positively correlated with the clinical neurological deficit score. Conclusion hs-CRP as an inflammatory marker plays an important role in the formation and progress of cerebral infarction, and it may reflect the severity of cerebral infarction patients, hs- CRP is critical in the diagnosis,monitoring and prognosis of the acute cerebral infarction.