| CD20在经典型霍奇金淋巴瘤HRS细胞中的表达及其与预后的关系 |
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| 引用本文： | 付晓红,王树森,黄岩,肖健,翟林柱,夏忠军,黄慧强,孙晓非,林桐榆. CD20在经典型霍奇金淋巴瘤HRS细胞中的表达及其与预后的关系[J]. 癌症, 2008, 27(11): 1197-1203 |
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| 作者姓名： | 付晓红 王树森 黄岩 肖健 翟林柱 夏忠军 黄慧强 孙晓非 林桐榆 |
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| 作者单位： | [1]华南肿瘤学国家重点实验室,广东广州510060 [2]中山大学肿瘤防治中心内科,广东广州510060 |
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| 摘 要： | 背景与目的:B淋巴细胞标记CD20在经典型霍奇金淋巴瘤(classicalHodgkin's lymphoma,CHL)HRS(Hodgkin and Reed-Sternberg)细胞的表达率为5%～58%.CD20表达对预测CHL预后的意义仍有争议.本研究旨在了解CD20在中国CHL HRS细胞中的表达情况及其与预后的关系.方法:收集1995年1月到2004年12月在中山大学肿瘤医院存档的70例初治CHL石蜡标本,HE染色和免疫组化法行CD20、CD15和CD30染色.以高于10%的HRS细胞胞膜表达CD20作为阳性标准.单因素分析采用log-rank检验,采用Cox部分风险模型进行多因素分析.结果:21例(30.0%)CHL HRS细胞CD20阳性,年龄≥45岁的CHL患者CD20的阳性率(53.3%)显著高于年龄<45岁患者(23.6%)(P=0.026).26例CHL(37.1%)患者CD15阳性,70例CHL均为CD30阳性.全组中位随访时间58.3个月,CD20( )组和CD20(-)组CHL 5年无失败生存率分别为76.2%和77.6%(P=0.484):5年总生存率分别为80.4%和92.5%(P=0.006).多因素分析显示,年龄和分期为CHL无失败生存和总生存的独立预后凶素.结论:CD20在CHL HRS细胞的阳性率为30%.年龄≥45岁CHL患者HRS细胞CD20阳性率显著高于年龄<45岁患者,但未能证实CD20是初治CHL无失败生存和总生存期的独立预后因素.
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| 关 键 词： | 霍奇金淋巴瘤 预后 免疫表型 |
Prognostic Significance of CD20 Expression in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin''s Lymphoma |
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| FU Xiao-Hong,,WANG Shu-Sen,HUANG Yan,XIAO Jian,ZHAI Lin-Zhu,XIA Zhong-Jun,HUANG Hui-Qiang,SUN Xiao-Fei,LIN Tong-Yu,.State Key Laboratory of Oncology in South China,Guangzhou,Guangdong,,P.R.China. Prognostic Significance of CD20 Expression in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin''s Lymphoma[J]. Chinese journal of cancer, 2008, 27(11): 1197-1203 |
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| Authors: | FU Xiao-Hong WANG Shu-Sen HUANG Yan XIAO Jian ZHAI Lin-Zhu XIA Zhong-Jun HUANG Hui-Qiang SUN Xiao-Fei LIN Tong-Yu .State Key Laboratory of Oncology in South China Guangzhou Guangdong P.R.China |
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| Affiliation: | FU Xiao-Hong1,2,WANG Shu-Sen1,HUANG Yan1,XIAO Jian1,ZHAI Lin-Zhu1,XIA Zhong-Jun1,HUANG Hui-Qiang1,SUN Xiao-Fei1,LIN Tong-Yu1,21.State Key Laboratory of Oncology in South China,Guangzhou,Guangdong,510060,P.R.China 2.Department of Medical Oncology,Cancer Center,Sun Yat-sen University,P.R.China |
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| Abstract: | BACKGROUND & OBJECTIVE:Hodgkin and Reed-Sternberg(HRS) cells of classical Hodgkin's Lymphoma(CHL) express B-cell marker CD20 with a reported frequency of 5%-58%.The prognostic significance of CD20 expression in HRS cells of CHL is still controversial.This study was to investigate the prognostic significance of CD20 expression in naive CHL patients.METHODS:The expression of CD20,CD15 and CD30 in 70 specimens of CHL were detected by immunohistochemistry;tumor morphology was observed with HE staining.A sample ... |
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| Keywords: | CD20 |
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