| HPLC法测定盐酸阿夫唑嗪片中盐酸阿夫唑嗪的含量 |
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| 引用本文： | 王守箐,徐斌,徐杰远.HPLC法测定盐酸阿夫唑嗪片中盐酸阿夫唑嗪的含量[J].齐鲁药事,2004,23(7):26-27. |
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| 作者姓名： | 王守箐 徐斌 徐杰远 |
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| 作者单位： | 1. 鲁南制药股份有限公司,临沂,276005
2. 临沂市药品检验所,临沂,276000 |
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| 摘 要： | 目的 建立用HPLC法测定盐酸阿夫唑嗪片中盐酸阿夫唑嗪含量。方法 以盐酸特拉唑嗪为内标,采用Alltima-CN柱,流动相为 0 0 5mol·L-1磷酸二氢钠溶液(0 5mol·L-1的氢氧化钠溶液调pH至 5 4 ) -乙腈(78∶2 2);检测波长:2 4 4nm。结果与结论 盐酸阿夫唑嗪在 5～ 5 0 μg·ml-1范围内呈良好的线性关系,回收率为 99 8%,RSD =0 9% (n =9)。
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| 关 键 词： | 盐酸阿夫唑嗪片 盐酸阿夫唑嗪 盐酸特拉唑嗪 高效液相色谱 |
| 文章编号： | 1672-7738(2004)07-0026-02 |
Determination of Alfuzosin hydrochloride in Alfuzosin hydrochloride Tablets by HPLC |
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| Wang Shou-qing,Xu Bin,Xu Jie-yuan.Determination of Alfuzosin hydrochloride in Alfuzosin hydrochloride Tablets by HPLC[J].qilu pharmaceutical affairs,2004,23(7):26-27. |
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| Authors: | Wang Shou-qing Xu Bin Xu Jie-yuan |
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| Institution: | Wang Shou-qing,Xu Bin,Xu Jie-yuan 1 |
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| Abstract: | Objective To establish a standard HPLC method for the determination of Alfuzosin hydrochloride in Alfuzosin hydrochloride Tablets.Methods Terazosin hydrochloride was used as internal standard,an Alltima-CN column was used with 0.05mol·L -1 NaH 2PO 4(pH 5.4,adjusted with 0.5mol·L -1 NaOH)-acetonitrile (78∶22) as mobile phase,and detected at a wavelength of 244nm.Results and Conlusion Alfuzosin hydrochloride was showed good linearity in the concentration of 5～50μg·ml -1,the average recovery was 99.8% with RSD of 0.9%(n=9). |
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| Keywords: | Alfuzosin hydrochloride Tablets Alfuzosin hydrochloride Terazosin hydrochloride HPLC |
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