Dynamic range and reproducibility of hepatitis B virus (HBV) DNA detection and quantification by Cobas Taqman HBV, a real-time semiautomated assay |
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| Authors: | Lindh Magnus Hannoun Charles |
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| Affiliation: | Department of Clinical Virology, G?teborg University, Guldhedsgatan 10B, 413 46 G?teborg, Sweden. magnus.lindh@microbio.gu.se |
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| Abstract: | The Cobas Taqman assay for hepatitis B virus (HBV) DNA showed linear detection over 7 logs for genotypes A to D. The coefficient of variation was 1.2% at > or =1,000 IU/ml and 22.0% at 10 IU/ml. In 97 clinical samples, the log HBV DNA/ml differed by 0.11 between Cobas Amplicor and Cobas Taqman (r2 = 0.97). |
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