新型药用辅料—泊洛沙姆407急性毒性初步研究

目的：了解泊洛沙姆407的急性毒性作用。方法：泊洛沙姆407凝胶昆明小鼠腹腔注射（ip），观察小鼠死亡率及血丙氨酸转移酶（ALT）、尿素氦（BUN）、总胆固醇（CH）及甘油三酯（TG）含量变化。结果：中、小剂量泊洛沙姆407小鼠ip对ALT、BUN无明显影响，但可致血脂一过性增高；小鼠ip25％泊洛沙姆407凝胶5．0g／kg，死亡率为50％。结论：泊洛沙姆407是一个毒性较低的药用辅料。

Acute Toxicity Test of a New Pharmaceutical Adjuvant─Poloxamer 407

OBJECTIVE: To study the acute toxicity of poloxamer 407.METHODS:The acute toxicity of poloxamer 407 gel wasevaluated on the basis of mortality rates and changes in alanine aminotransferase (ALT),blood urea nitrogen (BUN), cholesterol(CH)and triglycerides (TG) levels after intraperitoneal single dose injection (25%,0.1~0.4ml) to normal mice.RESULTS:ALT and BUNlevels had no significant change,however, blood lipid levels were incresed tomporarily at the doses of 1. 25 g / kg and 2. 5 g / kg and themortality rate was 50% at a dose of 5.0g ／ kg following intraperitoneal administration of poloxamer 407. CONCLUSIONS: Poloxamer407 is a good pharmaceutical adjuvant with low acute toxicity.