不同透皮促进剂对丹参贴膏离体透皮吸收的影响

本文报道了4种透皮促进剂3％月桂氮卓酮（Azone）＋5％丙二醇，3％Azone，5％丙二醇和5％二甲基亚砜（DMSO）对丹参贴膏中两种主要有效成分丹参素和原几条醛透皮吸收的影响。采用离体鼠皮为皮肤模型，实验装置应用自行设计的单室透皮扩散池，检测方法为高效液相色谱法。结果表明，4种透皮促进剂均可不同程度地促进丹参贴膏的透皮吸收效果，其中3％Azone＋5％丙二醇组成的二元透皮促进剂作用最显著。

The Effects of Four Transdermal Enhancers on Percutaneous Absorption of Salvia Miltiorrhize Adhesive Plaster

The effects of four transdermal enhancers on percutaneous sbsorption of the active components of Salvia Miltiorrhiza adhesive plaster, a preparation of traditional Chinese medicine, were investigated in single compartment diffusion cells. The enhances included 3% azone plus 5% propylene glycol, 5% dimethyl sulfoxide, 3% azone and 5% propylene glycol, the active components measured were Danshensu and Protocatechuic aldehyde. The results showed that above-mentioned four enhancers could promote absorption of active components through rat skin in different degrees with 3% azone plus 5% propylene glycol being the most effective one.