米力农对慢性心力衰竭患者利钾尿肽与心功能的影响

目的观察米力农治疗慢性心力衰竭的临床疗效及其对利钾尿肽(KP)的影响。方法选择慢性心力衰竭患者67例,随机分为米力农组32例和常规组35例,常规组予以常规治疗,米力农组在常规治疗基础上,静脉应用米力农0.75 μg/(kg·min)治疗7 d,治疗前后采用放射免疫法测定2组患者血浆KP,同时评价患者心功能改善情况。结果与治疗前比较,2组患者治疗后血浆KP水平明显下降(P0.01),而且米力农组血浆KP水平明显低于常规组(P0.01),心功能改善1～2级的比例较常规组高(P0.05)。与常规组治疗后比较,米力农组左心室高峰充盈率、LVEF和心指数明显升高,差异有统计学意义(P0.01)。结论应用米力农短期治疗慢性心力衰竭,很可能通过降低血浆KP水平改善患者心功能。

Effect of milrinone on kaliuretic peptide and heart function of congestive heart failure patients

Objective To observe the effect of milrinone on heart function and the plasma level of kaliuretic peptide(KP) in heart failure(CHF) patients.Methods Sixty-seven patients with CHF were enrolled in the study.The patients were randomly divided into milrinone group (32 cases) and control group(35 cases).The control group were treated with conventional drugs.Milrinone group were given intravenous milrinone for 7 days in addition to conventional treatment.The plasma level of KP was investigated before and after the treatment.Results The effective rate was higher in milrinone group than in control group.The cardiac function improved by 1 - 2 grades after milrinone treatment.The plasma level of KP in milrinone group was significantly declined after treatment than before and control group.Conclusion Milrinone is effective and safe for CHF and can decrease KP plasma level.