| 人体正常卵巢和卵巢肿瘤中雌激素及孕激素受体的研究 |
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| 引用本文： | 韩守威,曹泽毅,何斌,王靖华,陈曼玲. 人体正常卵巢和卵巢肿瘤中雌激素及孕激素受体的研究[J]. 四川大学学报(医学版), 1989, 0(3) |
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| 作者姓名： | 韩守威 曹泽毅 何斌 王靖华 陈曼玲 |
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| 作者单位： | 华西医大妇产科学教研室(韩守威，曹泽毅，何斌，王靖华)，华西医大生物化学教研室(陈曼玲) |
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| 摘 要： | 用葡聚糖-活性炭单点饱和分析法测定35例正常卵巢组织,75例良性病变及49例恶性卵巢组织的胞浆雌激素受体(ER)和孕激素受体(PR)。结果表明,恶性病变中,性腺间质类和上皮性恶性肿瘤,其ER、PR含量均高于生殖细胞来源的和转移性癌(ER:P<0.05,PR:P<0.025);上皮性恶性肿瘤中,内膜样癌的ER和PR含量高于桨液性、粘液性及透明细胞癌(ER:P<0.05,PR:P<0.01)。提示受体含量高者有用内分泌治疗的可能和推测有较好的预后。卵巢恶性肿瘤组织ER和PR含量与患者月经状况,临床分期及肿瘤的分化程度均无明显关联。
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| 关 键 词： | 卵巢肿瘤 雌激素受体 孕激素受体 葡聚糖-活性炭单点饱和分析法 |
ESTROGEN AND PROGESTERONE RECEPTORS IN HUMAN OVARY AND OVARIAN TUMORS |
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| Han Shouwei,Cao Zeyi,He Bin,Wang Jinghua,Chen Manling. ESTROGEN AND PROGESTERONE RECEPTORS IN HUMAN OVARY AND OVARIAN TUMORS[J]. Journal of Sichuan University. Medical science edition, 1989, 0(3) |
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| Authors: | Han Shouwei Cao Zeyi He Bin Wang Jinghua Chen Manling |
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| Affiliation: | Han Shouwei;Cao Zeyi;He Bin;Wang Jinghua;Chen Manling Department of Obstetrics and Gynecology Department of Biochemistry |
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| Abstract: | Ovarian specimens from 159 different patients were analyzed for estrogen andprogesterone receptor (ER and PR) contentwith the Dextran-coated Charcoal method. The results indicated that the contents of ER and PR in malignant ovarian tumors were not correlated with the menstrual cy-cle of the patient, clinical and differ-entiation of the tumor.Among malignant ovarian tumors, the mean ER and PR con-centrations in sex-cord stromal tumors andendometrioid carcinomas were higher than those in other malignant ovarian tumors(P<0.05, P<0.025). This suggests the pos-sibility of endocrine therapy for these pa-tients with the hope for a better prognosis. |
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| Keywords: | Ovarian tumor Estrogen receptor Progesterone receptor Dextran-coated Charcoal single-point-saturable analysis |
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