| 器官移植术后嵌合现象的研究 |
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| 引用本文： | 江志伟,黎介寿,李宁,尹路,李幼生,陈永明.器官移植术后嵌合现象的研究[J].医学研究生学报,1995(2). |
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| 作者姓名： | 江志伟 黎介寿 李宁 尹路 李幼生 陈永明 |
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| 作者单位： | 南京军区南京总医院解放军普外专科中心!南京，210002(江志伟，黎介寿，李宁，尹路，李幼生)，南京 (陈永明) |
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| 摘 要： | 选择3例接受男性移植物的女性移植患者作为研究对象，其中1例小肠移植，2例肾移植患者，利用PCR技术扩增Y染色体特异性DNA片段，结果在小肠移植女性受体外周血及皮肤组织中出现Y染色体特异性DNA片段，肾移植外周血中也出现Y染色体特异性DNA片段，表明在器官移植术后存在着供体细胞向受体组织的移居嵌合。联合的发现不仅丰富了免疫耐受的理论，而且对移植临床具有指导意义。促进嵌合的出现及保持嵌合的平衡，将有利于防治排异反应和GVHD。
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| 关 键 词： | 器官移植 嵌合 PCR技术 |
Study of organ transplantation chimerism |
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| Jiang Zhiwei,Li jieshou,Li nin,et al.Study of organ transplantation chimerism[J].Bulletin of Medical Postgraduate,1995(2). |
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| Authors: | Jiang Zhiwei Li jieshou Li nin |
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| Institution: | Department of Abdominal Surgery |
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| Abstract: | Three female patients recieved male donor grafts, one was total small bowel transplantation, two were renal transplantation. PCR to detect a Y chromosome specifical DNA sequence was employed to identify the presence of donor cell based on sex difference between donor and recipient. Y chromosome specifical DNA sequence were found in peripheral blood andskin of small bowel recipient,in periphral blood of renal recipients. The results indicated that donor cells migrated to recipient tissue. Chirnerism is significant to immunological tolerance and clinical transplantation practice. |
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| Keywords: | organ transplantation chimerism PCR technique |
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