| 造血干细胞移植中出血性膀胱炎的防治研究 |
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| 引用本文： | 孟向尚,史春雷,袁成录,王红娟. 造血干细胞移植中出血性膀胱炎的防治研究[J]. 中国药房, 2006, 17(12): 932-933 |
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| 作者姓名： | 孟向尚 史春雷 袁成录 王红娟 |
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| 作者单位： | 山东青岛市中心医院,青岛市,266042 |
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| 摘 要： | 目的探讨外周血造血干细胞移植(PBSCT)中出血性膀胱炎(HC)的发病机制及防治方法。方法19例PBSCT患者进行水化、利尿、碱化、应用美司钠及抗病毒治疗,对HC的危险因素和临床疗效进行分析。结果19例PBSCT患者中,1例出现HC。结论HC的发生除与环磷酰胺、马利兰、全身照射的损害有关外,还与移植物抗宿主病及病毒感染有关。在常规水化、碱化、利尿基础上加用美司钠和抗病毒治疗,可降低HC的发生率。
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| 关 键 词： | 造血干细胞移植 出血性膀胱炎 防治 |
| 文章编号： | 1001-0408(2006)12-0932-02 |
| 收稿时间： | 2006-03-24 |
| 修稿时间： | 2006-05-09 |
Study on Prevention and Treatment of Hemorrhagic Cystitis in Hematopoietic Stem Cell Transplantation Recipients |
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| MENG Xiangshang,SHI Chunlei,YUAN Chenglu,WANG Hongjuan. Study on Prevention and Treatment of Hemorrhagic Cystitis in Hematopoietic Stem Cell Transplantation Recipients[J]. China Pharmacy, 2006, 17(12): 932-933 |
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| Authors: | MENG Xiangshang SHI Chunlei YUAN Chenglu WANG Hongjuan |
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| Affiliation: | Central Hospital of Qingdao City, Qingdao 266042, China |
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| Abstract: | OBJECTIVE:To study the pathogenesis,prevention and treatment of the hemorrhagic cystitis(HC)in the peripheral blood stem cell transplantation(PBSCT)recipients.METHODS:19 patients undertaking PBSCT were given treatment of hyperhydration,diuresis,alkalinizing,mensa and antivirus medicine.The clinical risk factors and outcomes of the HC were analyzed.RESULTS:Only 1 of the 19 patients developed HC.CONCLUSION:Besides some chemiotherapy regimens such as cyclophosphamide,busulfan and TBI,GVHD and virus infection are the risk factors of HC.And extra use of mensa and antivirus medicine combined with routive hyperhydration,diuresis and alkalinizing can decrease the incidence of HC. |
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| Keywords: | Hematopoleyic stem cell transplantation Hemorrhagic cystitis Prevention and treatment |
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