Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway |
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| Authors: | Peixin Dong Zhujie Xu Nan Jia Dajin Li Youji Feng |
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| Institution: | (1) Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, PR, China;(2) Department of Cardiovascular Medicine, Kanglian Hospital, Shanghai, PR, China;(3) Department of Cardiology, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, PR, China |
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| Abstract: | Background p53 is the most commonly mutated tumor suppressor gene in human cancers. In addition to the loss of tumor suppression function
and exertion of dominant-negative effects over the remaining wild-type protein, several p53 mutants can gain novel oncogenic
functions (gain-of-function, GOF) that actively regulate cancer development and progression. In human endometrial cancer,
p53 mutation is more often associated with aggressive nonendometrioid cancer. However, it was unknown if p53 mutants contributed
to endometrial cancer progression through the GOF properties. |
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