| 糖尿病大鼠肾皮质糖基化终产物含量与纤溶酶原激活物抑制物-1表达的关系 |
| |
| 引用本文： | 李才,侯芳玉,张国军,苗春生,邹雅斌. 糖尿病大鼠肾皮质糖基化终产物含量与纤溶酶原激活物抑制物-1表达的关系[J]. 吉林大学学报(医学版), 2002, 28(6): 571-573. DOI: 10.3969/j.issn.1671-587X.2002.06.002 |
| |
| 作者姓名： | 李才 侯芳玉 张国军 苗春生 邹雅斌 |
| |
| 作者单位： | 1. 吉林大学药学院,吉林长春,130021;2. 吉林大学基础医学院 |
| |
| 基金项目： | 卫生部科研项目;962181; |
| |
| 摘 要： | 目的:研究链脲佐菌素诱发的糖尿病(DM)大鼠肾皮质糖基化终产物(AGEs)含量与纤溶酶原激活物抑制物-1(PAI-1)表达的关系及牛磺酸的调节作用.方法:DM大鼠用牛磺酸处理14周后,分别用荧光法、生物化学法和Northern杂交检测肾皮质AGEs含量、组织型纤溶酶原激活物(t-PA)活性、PAI-1活性和PAI-1 mRNA表达.结果:与对照大鼠相比,DM大鼠肾皮质AGEs含量、PAI-1活性和PAI-1 mRNA表达明显增加,而t-PA活性下降.AGEs含量与PAI-1生物活性及PAI-1 mRNA表达均呈正相关(P<0.01).DM大鼠给予牛磺酸处理后可改善上述参数的改变.结论:DM大鼠肾皮质AGEs含量增加能明显上调PAI-1基因表达,牛磺酸可抑制AGEs形成和PAI-1基因表达的上调.
|
| 关 键 词： | 糖基化终产物 纤溶酶原激活物抑制物-1 糖尿病 牛磺酸 |
| 文章编号： | 1671-587X(2002)06-0571-03 |
| 修稿时间： | 2002-02-04 |
Relationship between advanced glycation end product content and plasminogen activator inhibitor-1 expression in renal cortex of diabetic rats |
| |
| LI Cai ,HOU Fang yu ,ZHANG Guo jun ,MIAO Chun sheng ,ZOU Ya bin. Relationship between advanced glycation end product content and plasminogen activator inhibitor-1 expression in renal cortex of diabetic rats[J]. Journal of Jilin University: Med Ed, 2002, 28(6): 571-573. DOI: 10.3969/j.issn.1671-587X.2002.06.002 |
| |
| Authors: | LI Cai HOU Fang yu ZHANG Guo jun MIAO Chun sheng ZOU Ya bin |
| |
| Affiliation: | LI Cai 1,HOU Fang yu 2,ZHANG Guo jun 1,MIAO Chun sheng 1,ZOU Ya bin 1 |
| |
| Abstract: | Objective:To investigate the relationship between the advanced glycation end products(AGEs) content and plasminogen activator inhibitor 1 (PAI 1) gene expression in renal cortex of streptozotocin induced diabetic rats and its modulation by taurine. Methods:The fluorescence method, biochemical technique and Northern blot analysis were used to detect the AGE content, tissue plasminogen activator(t PA)activity,PAI 1 activity and PAI 1 mRNA expression, respectively. Results:Compared with control animals, diabetic rats showed an increase in AGE content,PAI 1 activity and PAI 1 mRNA expression,and a decrease in t PA activity in renal cortex. AGE content was positively correlated with PAI 1 activity and PAI 1mRNA expression. Administration of taurine to diabetic rats improved the changes of these parameters. Conclusion:The increased AGE content in renal cortex of diabetic rats can markedly upregulate PAI 1 mRNA expression, and taurine suppresses AGEs formation and PAI 1 mRNA expression. |
| |
| Keywords: | advanced glycation end products plasminogen activator inhibitor 1 diabetes mellitus taurine |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
