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| 中药壁虎化学成分研究 | |
| 引用本文： | 李雯,王国才,张晓琦,王英,叶文才. 中药壁虎化学成分研究[J]. 中国中药杂志, 2010, 35(18): 2412-2415 |
| 作者姓名： | 李雯 王国才 张晓琦 王英 叶文才 |
| 作者单位： | 1. 中国药科大学,天然药物化学教研室,江苏,南京,210009;中药药效物质基础及创新药物研究广东省高校重点实验室,广东,广州,510632 2. 暨南大学,中药及天然药物研究所,广东,广州,510632;中药药效物质基础及创新药物研究广东省高校重点实验室,广东,广州,510632 3. 中国药科大学,天然药物化学教研室,江苏,南京,210009;暨南大学,中药及天然药物研究所,广东,广州,510632;中药药效物质基础及创新药物研究广东省高校重点实验室,广东,广州,510632 |
| 摘 要： | 目的:对壁虎科动物无蹼壁虎Gekko swinhonis的化学成分进行研究。方法:采用硅胶Sephadex LH-20,ODS及HPLC等柱色谱法进行分离纯化,根据理化性质和波谱数据鉴定化合物结构。结果:分离得到13个化合物,分别鉴定为环(脯氨酸-亮氨酸)[cyclo-(Pro-Leu),1],环(丙氨酸-脯氨酸)[cyclo-(Ala-Pro),2],环(甘氨酸-脯氨酸)[cyclo-(Gly-Pro),3],环(丙氨酸-缬氨酸)[cyclo-(Ala-Val),4],6-氨基嘌呤核苷(6-amino-9-β-D-ribofuranosyl-9H-purine,5),尿嘧啶核苷(uridine,6),脱氧胸苷(thymidine,7),次黄苷(hypoxanthine-9-β-D-ribofuranosid,8),L-苯丙氨酸(L-phenylalanine,9),5α-胆甾-3,6-二酮(5α-cho-lest-3,6-dione,10),胆甾醇(cholesterol,11),十六烷酸单甘油酯(1-O-hexadecanolenin,12),硬脂酸(octadecanoic acid,13)。结论:13个化合物均为首次从中药壁虎中分离得到。 |
| 关 键 词： | 壁虎 化学成分 环二肽 |
| 收稿时间： | 2009-11-04 |
Chemical constituents of Gekko swinhonis |
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| LI Wen,WANG Guocai,ZHANG Xiaoqi,WANG Ying and YE Wencai. Chemical constituents of Gekko swinhonis[J]. China Journal of Chinese Materia Medica, 2010, 35(18): 2412-2415 | |
| Authors: | LI Wen WANG Guocai ZHANG Xiaoqi WANG Ying YE Wencai |
| Affiliation: | Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China;Guangdong Province Key Laboratory of Pharmaceutical Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University,Guangzhou 510632, China;Institute of Traditional Chinese Medicine & Natural Products,Jinan University,Guangzhou 510632,China;Guangdong Province Key Laboratory of Pharmaceutical Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University,Guangzhou 510632, China;Institute of Traditional Chinese Medicine & Natural Products,Jinan University,Guangzhou 510632,China;Guangdong Province Key Laboratory of Pharmaceutical Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University,Guangzhou 510632, China;Institute of Traditional Chinese Medicine & Natural Products,Jinan University,Guangzhou 510632,China;Guangdong Province Key Laboratory of Pharmaceutical Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University,Guangzhou 510632, China;Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China;Institute of Traditional Chinese Medicine & Natural Products,Jinan University,Guangzhou 510632,China;Guangdong Province Key Laboratory of Pharmaceutical Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University,Guangzhou 510632, China |
| Abstract: | |
| Keywords: | Gekko swinhonis chemical constituent cyclodipeptides |
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