Dose-dependent kinetics of caffeine in rats |
| |
| Authors: | R. Latini M. Bonati D. Castelli S. Garattini |
| |
| Affiliation: | Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea, 62 — 20157 MilanItaly |
| |
| Abstract: | Caffeine was administered orally to male rats at 3 different doses (1, 10, 100 mg/kg). Plasma and brain concentrations were measured and kinetic parameters calculated. Ratios between doses were much lower than between areas under the curve in plasma as well as in brain. Brain:plasma ratios changed with the dose. Dose-dependent kinetics of caffeine in elimination and absorption is apparent. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
