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Effect of chronic lead treatment on brain dopamine synthesis and serum prolactin release in the rat |
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| Authors: | S. Govoni O. Montefusco P.F. Spano M. Trabucchi |
| Affiliation: | Department of Pharmacology, University of Brescia Italy |
| Abstract: | The effect of chronic dietary lead exposure on brain striata dopaminergic transmission was studied in rats by measuring dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels. Serum prolactin (PRL) concentration was also measured. The results show a decreased striatal dopamine synthesis and increased serum PRL concentrations. |
| Keywords: | DOPAC dihydroxyphenylacetic acid HVA homovanillic acid α-MPT α-methylparatyrosine PRL prolactin |
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