Effect of vitamin C on paracetamol hepatotoxicity

Vitamin C and paracetamol are known to compete for the sulphate pool in the body. Hence the effect of vitamin C on paracetamol hepatotoxicity was studied. In therapeutic doses, simultaneous administration of Vitamin C and paracetamol did not result in liver dysfunction in undernourished subjects as judged by serum GOT and γ-GT levels. On the other hand, even after toxic doses of paracetamol, Vitamin C may have a protective role in mice possibly through its antioxidant property.