| 复方黄根对小鼠免疫性肝损伤的保护作用 |
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| 引用本文： | 邓家刚,郑作文,王勤,秦华珍,王硕,周小雷. 复方黄根对小鼠免疫性肝损伤的保护作用[J]. 中国实验方剂学杂志, 2007, 13(5): 37-39 |
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| 作者姓名： | 邓家刚 郑作文 王勤 秦华珍 王硕 周小雷 |
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| 作者单位： | 广西中医学院,广西,南宁,530001 |
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| 基金项目： | 广西科技厅科技攻关资助项目桂科攻（0235023-1）;桂科能（0630006-5A） |
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| 摘 要： | 目的：研究复方黄根对小鼠免疫性肝损伤的保护作用。方法：采用卡介苗（BCG）＋脂多糖（LPS）造成免疫性肝损伤动物模型,观察复方黄根对小鼠血清各（ALT）、（AST）活性及肝组织匀浆超氧化酶歧化酶（SOD）、（MDA）、谷胱甘肽过氧化物酶（GSH-PX）水平的影响,并观察肝组织病理学改变。结果：复方黄根可明显降低小鼠血清中ALT、AST活性;减少肝匀浆MDA含量,并能使肝匀浆降低的SOD、GSH-PX活性升高。结论：复方黄根有明显的保肝作用,其抗氧化保肝作用可能与抗脂质过氧化有关。
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| 关 键 词： | 复方黄根 免疫性肝损伤 保肝 抗氧化 |
| 文章编号： | 1005-9903（2007）05-0037-03 |
| 收稿时间： | 2006-10-31 |
| 修稿时间： | 2006-10-31 |
Protective Effects of Compound Huanggen on Immunological Liver lnjury |
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| DENG Jia-gang,ZHENG Zuo-wen,WANG Qin,Qin Hua-zhen,WANG Shuo,ZHOU Xiao-lei. Protective Effects of Compound Huanggen on Immunological Liver lnjury[J]. China Journal of Experimental Traditional Medical Formulae, 2007, 13(5): 37-39 |
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| Authors: | DENG Jia-gang ZHENG Zuo-wen WANG Qin Qin Hua-zhen WANG Shuo ZHOU Xiao-lei |
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| Affiliation: | Guangxi Traditional Chinese Medical University, Nanning 530001, China |
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| Abstract: | Objective:To investigate the protective effect of Compound Huanggen on immunological liver injury in mice.Method:The model of hepatic damage was induced by BCG+LPS.The ALT and AST level in serum and MDA,SOD,GSH-PX activites in liver homogenate were assayed and dimensions of hepatic damage in the histopathology were observed.Results:Compound Huanggen was found to significantly decrease the serum transaminase activities,Meanwhile decreased MDA content and inhilited SOD,GSH-PX activities in liver homogenate.Conclusion:Compound Huanggen show significant protective action on immunological liver injury in mice. |
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| Keywords: | Compound Huanggen immunological liver injury hepatoprotection antioxident activity |
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