| 结核分枝杆菌抗原Rv1258c、Rv1410c及Rv3425的HLA限制性CTL表位预测 |
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| 引用本文： | 朱宇皇,高艳锋,吕虹,祁元明. 结核分枝杆菌抗原Rv1258c、Rv1410c及Rv3425的HLA限制性CTL表位预测[J]. 郑州大学学报(医学版), 2011, 46(1): 13-15 |
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| 作者姓名： | 朱宇皇 高艳锋 吕虹 祁元明 |
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| 作者单位： | 郑州大学生物工程系,郑州,450001 |
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| 基金项目： | 国家自然科学基金资助项目30872381; 河南省杰出人才基金资助项目084200510014 |
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| 摘 要： | 目的:预测结核分枝杆菌(MTB)相关抗原Rv1258c、Rv1410c及Rv3425的HLA限制性细胞毒性T细胞(CTL)表位.方法:通过NCBI数据库获取各蛋白的氨基酸序列,利用BLAST分析其与人类蛋白质的同源性,利用SYFPEITHI、BIMAS和NetCTL数据库预测分析MTB相关抗原的HLA-A2与HLA-A...
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| 关 键 词： | 结核分枝杆菌 Rv1258c Rv3425 Rv1410c 表位预测 |
Prediction of HLA restricted CTL epitopes in Mycobacterium tuberculosis antigens Rv1258c,Rv1410c and Rv3425 |
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| ZHU Yuhuang , GAO Yanfeng , LV Hong , QI Yuanming. Prediction of HLA restricted CTL epitopes in Mycobacterium tuberculosis antigens Rv1258c,Rv1410c and Rv3425[J]. Journal of Zhengzhou University: Med Sci, 2011, 46(1): 13-15 |
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| Authors: | ZHU Yuhuang GAO Yanfeng LV Hong QI Yuanming |
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| Affiliation: | ZHU Yuhuang,GAO Yanfeng,LV Hong,QI Yuanming Department of Bioengineering,Zhengzhou University,Zhengzhou 450001 |
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| Abstract: | Aim:To predict the HLA restricted cytotoxic T lymphocyte(CTL)epitopes in Mycobacterium tuberculosis antigens Rv1258c,Rv1410c and Rv3425.Methods:The amino acid sequences of the antigens were obtained from NCBI database.Their homologies to human proteins were analyzed by BLAST.HLA-A2-and HLA-A3-restricted CTL epitopes were predicted by SYFPEITHI,BIMAS and NetCTL.Results:The predominant HLA-A2-and HLA-A3-restricted CTL epitopes predicted from the three candidate antigens were Rv1258c 343~351,380~388,290~298,52... |
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| Keywords: | Mycobacterium tuberculosis Rv1258c Rv3425 Rv1410c epitope prediction |
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