Effect of 450-mg loading dose of clopidogrel on platelet function in Japanese patients undergoing coronary stent placement |
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Authors: | Kenichi Fukushima Yoshio Kobayashi Hideki Kitahara Yo Iwata Nakabumi Kuroda Masayuki Ooyama Fumio Nomura Issei Komuro |
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Institution: | (1) Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba Chiba, 260-8677, Japan; |
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Abstract: | Usefulness of higher (>300 mg) loading doses of clopidogrel has been demonstrated in studies from the United States and Europe.
The present study evaluated platelet aggregation after the administration of a 450-mg loading dose of clopidogrel in Japanese
patients undergoing coronary stenting. Platelet aggregation was serially measured at baseline, and 2, 4, 6, and 8 h after
450-mg clopidogrel loading in 25 patients undergoing coronary stenting. Platelets were stimulated with 5 and 20 μmol/l adenosine
diphosphate (ADP) and aggregation was assessed by optical aggregometry. Platelet aggregation (5 μmol/l ADP 42.8% ± 13.5% and
20 μmol/l ADP 51.2% ± 11.6%) was significantly suppressed ≤4 h after 450-mg clopidogrel loading. There were no adverse events
except one minor nasal bleed. The present study shows that platelet inhibition is achieved ≤4 h after the administration of
a 450-mg clopidogrel loading dose in Japanese patients. |
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