安胎清肝法治疗妊娠期慢性乙型病毒性肝炎的临床研究

目的 观察安胎清肝方药治疗妊娠期慢性乙型病毒性肝炎的疗效。方法 选择胎药菟丝子，黄芪，黄芩等和清肝药叶下珠，蒲公英等组成安胎清肝方治疗妊娠期慢性乙型病毒性肝炎50例，观察治疗后妊娠情况，肝功能，乙肝病毒标志物和肝纤维化指标的变化。结果 经治疗后无1例出现流产，谷丙转氨酶，血清胆红素，血清透明质酸等均明显降低，与治疗前比较，差异均有显著性（P＜0．01）；HBeAg和HBV－DNA的阴转率分别达到30％和32．5％。结论 安胎清肝法对妊娠期慢性乙型病毒性肝炎有较好的保胎，护肝作用。

Clinical Study of Fetus- soothing and Liver- clearing Therapy for Pregnancy Associated with Chronic Hepatitis B

[ Objective] To observe the therapeutic effect of fetus - soothing and liver - clearing therapy for pregnancy associated with chronic hepatitis B. [Methods] Fifty cases of pregnancy associated with chronic hepatitis B were treated with fetus - soothing and liver - clearing Decoction, which is mainly composed of Semen Cuscutae, Radix Astragali, Radix Scutellariae, Herba Phyllanthus and Herba Taraxaci. After treatment, general state of gravida, indexes of hepatic function, hepatitis B virus (HBV) marker and hepatic fibrosis were detected. [Results] No miscarriage was found in the cases. Serum levels of glutamic - pyruvic transaminase, bilirubin and hyaluronic acid ( HA) were decreased obviously , the difference being significant as compared with those before treatment ( P < 0.01). Ratios of HBeAg becoming negative and HBV- DNA becoming negative were 30.0% and 32.5% . [Conclusion] Fetus - soothing and liver -clearing therapy exerts a good effect in preventing miscarriage and protecting liver for pregnancy associated with chronic hepatitis B.