娑罗子提取物对阿司匹林致胃溃疡作用的研究

目的研究娑罗子提取物（SAE）对阿司匹林所致胃溃疡的保护作用,为阿司匹林安全用药提供依据。方法用阿司匹林制备溃疡模型,小鼠连续5天灌胃给予SAE（3.5、7、14mg/kg）或在制备溃疡模型前、后不同时间点灌胃给予SAE（7mg/kg）,于显微镜下观察胃溃疡指数。结果与模型组比较,SAE（7、14mg/kg）显著降低溃疡指数（P〈0.05）。制备溃疡模型同时给予SAE（7mg/kg）可以明显降低溃疡指数。结论娑罗子提取物对阿司匹林所致胃溃疡有预防作用。

The Protective Effect of Semen Aesculi Extracts on Gastric Ulcer Induced by Aspirin

Objective To study the protective effect of Semen Aesculi extracts（SAE） on gastric ulcer induced by aspirin in mice. Methods The gastric ulcer was induced by aspirin. SAE（3.5,7,14 mg/kg） were administered orally once daily for five consecutive days,or the SAE （7mg/kg） was administered orally before or after the administration of aspirin. The gastric mucosa was examined under a dissecting microscope. Results The level of gastric mucosal lesions was lower in mice treated by SAE（7 or 14 mg/kg）（P〈0.05）. Simultaneous SAE（7mg/kg） administration with aspirin treatment attenuated the level of gastric mucosal lesions. Conclusion Semen Aesculi extracts can protect the mice from gastric ulcer induced by aspirin.