颅内压增高型囊虫病的治疗

报告123例颅内压增高型脑囊虫病治疗的结果(吡喹酮88例,丙硫咪唑35例)。根据严格的确诊标准,治疗结束后半年全面复查按六项标准评效。吡喹酮组:痊愈15.9％,显效36.4％。16例已随访三年,疗效稳定。7例治疗前后CT所见与疗效吻合。治疗前后的生活质量有显著改变。丙硫咪唑组未显示确切效果,因病例数少,剂量分散,也不能肯定其无效。重点讨论了治疗的严重副反应,本组吡喹酮的死亡率高达10.2％。着重分析了颅内压增高反应的发生规律。认为主要是广泛大量脑实质内囊包患者的反应大,年轻、临床表现为脑(氵弥)散损伤及颅压增高严重者应特别警惕。提出了改进治疗的七项建议。

The Treatment of Brain Cysticercosis with Intracranial Hypertension

Result of treatment of 123 cases of Brain cysticercosis with intracranial hypertension was presented (Praziquantel 88 cases, Ibendazolt 35 cases) . All the cases met the strict diagnostic criteria, and have a check up at least 6 months after treatment. Effectiveness was evaluated basing on a 6-item standard.Result of Treatment: For praziquantel group, cure rate was 15.9% marked improvement 36.4% 16 cases in the group have deen followed up for 3 years.There were no recurrence. Effectiveness could be established with certainty. The CT findings that multiple low density areas before treatment disappeared or were transformed to hyperdensiity nodules after treatment were consistent with the symptomatic inprovement kedly Living quality of patients was mar kedly improved after the therapy. Asfor albendazole group, nosignificant number of patients and diverse dosage usediin this guoup.Side Effect. This article stressed the serious side effet of the therapy. In Praziquantel group, mortality rate was as high as 10.2% (9 cases) , Factors regarding malignant intracranial h hypertension afeer treatment was analy analysed, Thoseewho had lage amount of disiminated cysts locating in brain substsnce apparently gave more serious side effects. Younger age and clinical evidences of diffuse brain sympotom (conscious changes and mental symptom) and serious intracranial hypertension (choked disc with hemorrage) were shown statistically to be relevant with serious side effects.Seven suggestions were proposed to improve the treatment routine.