| Effects of glycoprotein Ⅱb/Ⅲa antagonists and chloride channel blockers on platelet cytoplasmic free calcium |
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| 作者姓名： | Yin SM Xie SF Nie DN Li YQ Li HM Ma LP Wang XJ Wu YD Feng JH |
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| 作者单位： | Department of Hematology, 2nd Affiliated Hospital of Sun Yat-SenUniversity, Guangzhou 510120, China |
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| 基金项目： | This study was supported by the grants from Guangdong Sci-tech Plan Project （No. 2003C32709） and Guangdong Key Research Project （No. 99M04810G） |
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| 摘 要： | Platelet activation plays an important role in thrombosis. Platelet glycoprotein Ⅱ b/Ⅲ a （ GPⅡ b/Ⅲ a ） is the receptor of fibrinogen. Platelet cross-linking with fibrinogen through GP Ⅱ b/Ⅲ a is the process of thrombosis. Ca^2＋ is an important intracellular second messenger in platelet activation. It has been reported that GP Ⅱ b/Ⅲ a receptors were involved in the calcium influx of activated platelet, and GP Ⅱ b/Ⅲ a receptor had characteristics of calcium channel or an adjacent calcium channel.
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| 关 键 词： | 糖蛋白Ⅱb 糖蛋白Ⅲa 氯化物 雏形锻模 血小板 细胞质 钙元素 |
| 收稿时间： | 2005-09-17 |
Effects of glycoprotein IIb/IIIa antagonists and chloride channel blockers on platelet cytoplasmic free calcium |
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| Yin SM,Xie SF,Nie DN,Li YQ,Li HM,Ma LP,Wang XJ,Wu YD,Feng JH.Effects of glycoprotein IIb/IIIa antagonists and chloride channel blockers on platelet cytoplasmic free calcium[J].Chinese Medical Journal,2005,118(23):2020-2024. |
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| Authors: | Yin Song-mei Xie Shuang-feng Nie Da-nian Li Yi-qing Li Hai-ming Ma Li-ping Wang Xiu-ju Wu Yu-dan Feng Jian-hong |
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| Institution: | Department of Hematology, 2nd Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China |
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| Abstract: | |
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| Keywords: | platelet glycoprotein Ⅱb/Ⅲa antagonists chloride channel blockers |
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