急性白血病患者治疗前后血浆VEGF水平的临床意义

目的：探讨急性白血病患者血管内皮生长因子水平的变化。方法：应用酶联双抗体夹心法测定了34例急性白血病患者血管内皮生长因子的含量，并与35名正常健康人作比较。结果：急性白血病患者在治疗前血管内皮生长因子含量非常显著地高于正常人组（P〈0．01），经抗癌和中西医结合治疗三个月后与正常人组比较，仍有显著性差异（P〈0．05）。结论：急性白血病的发生与发展与血管内皮生长因子水平密切相关。

Clinical Significance of Determination of Changes of Plasma Vascular Endothelial Growth Factor (VEGF) Contents After Treatment in Patients with Acute Leukemia

Objective To investigate the changes of plasma VEGF after treatment in patients with acute leukemia.Methods Plasma VEGF levels were determined with(ELISA) in 34 patients with acute leukemia both before and after treatment as well as in 35 controls.Results Before treatment the plasma levels of VEGF levels in patients were significantly higher than those in the controls(P<0.01).After three months of treatment the levels dropped markedly but still remained significantly higher than those in controls(P<0.05).Conclusion Development of acute leukemia was closely related to the plasma levels of VEGF.