No association between SOD2 Val16Ala polymorphism and breast cancer susceptibility: a meta-analysis based on 9,710 cases and 11,041 controls |
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Authors: | Xiangyu Ma Chunhai Chen Hongyan Xiong Jin Fan Yafei Li Hui Lin Rufu Xu Guorong Huang and Bin Xu |
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Institution: | (1) Department of Epidemiology, Faculty of Preventive Medicine, Third Military Medical University, Gaotanyan Street 30, Chongqing, 400038, China;(2) Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, Gaotanyan Street 30, Chongqing, 400038, China;(3) Department of Neurology, Jinling Hospital, Nanjing, Jiangsu Province, China; |
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Abstract: | Breast cancer is the most common cancer in women worldwide, but its etiology is still unclear. It is believed that oxidative
stress plays an essential role in the development of breast cancer, while SOD2 is one of the primary enzymes that directly
convert potential harmful oxidizing species to harmless metabolites. The association of SOD2 Val16Ala polymorphism and breast
cancer risk has been widely reported, but results of previous studies were somewhat contradictory and underpowered. To overcome
the limitations of individual study and to understand the real situation, we conducted a systematic review and meta-analysis
toward the association between SOD2 Val16Ala polymorphism and breast cancer. Through retrieving MEDLINE, PubMed, Embase, and
Web of Science, a total of 17 studies with 9,710 cases and 11,041 controls were identified. The results showed that no significant
associations were found for the allele contrast (allele Ala vs. allele Val: OR = 1.020, 95% CI = 0.979–1.062), additive genetic
model (Ala/Ala vs. Val/Val: OR = 1.091, 95% CI = 0.969–1.229), dominant genetic model (Ala/Ala +Ala/Val vs. Val/Val: OR = 1.045,
95% CI = 0.961–1.136), and recessive genetic model (Ala/Ala vs. Val/Val +Ala/Val: OR = 1.027, 95% CI = 0.956–1.102). In the
stratified analysis by ethnicity and menopausal status, significant associations were also not detected in all genetic models.
Conclusively, this meta-analysis strongly suggests that SOD2 Val16Ala polymorphism is not associated with breast cancer susceptibility. |
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