Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity |
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| Authors: | Debiak Malgorzata Kehe Kai Bürkle Alexander |
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| Affiliation: | Molecular Toxicology Group, Department of Biology, Box X911, University of Konstanz, 78457 Konstanz, Germany. |
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| Abstract: | Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury. |
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| Keywords: | Sulfur mustard PARP DNA repair Cell death NAD+ 3-Aminobenzamide |
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