首页 | 本学科首页   官方微博 | 高级检索  
     


Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity
Authors:Debiak Malgorzata  Kehe Kai  Bürkle Alexander
Affiliation:Molecular Toxicology Group, Department of Biology, Box X911, University of Konstanz, 78457 Konstanz, Germany.
Abstract:Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury.
Keywords:Sulfur mustard   PARP   DNA repair   Cell death   NAD+   3-Aminobenzamide
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号