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Significant Impact of IL-6 -174G/C but Inverse Relation with -634 C/G Polymorphism in Patients with Non-Small Cell Lung Cancer in Kashmiri Population |
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| Authors: | Imtiyaz A. Bhat Iqbal Qasim Khalid Z. Masoodi Shabeer A. Paul Bashir A. Bhat Roohi Rasool |
| Affiliation: | 1. Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India,;2. Division of Biotechnology, SKUAST Kashmir, Shalimar, Srinagar, India,;3. Department of General Medicine, Sher-i-Kashmir Institute of Medical Sciences, Medical College, Bemina, Srinagar, India,;4. Department of Plastic Surgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India, and |
| Abstract: | To study the possible role of proinflammatory interleukin 6 -174 G>C (rs 1800795) and -634 C>G (rs 1800796) polymorphism in the pathogenesis of non-small cell lung cancer (NSCLC). A total of 190 NSCLC patients and 200 healthy controls were evaluated for polymorphic analysis of -174 G/C and -634 C/G by PCR-RFLP followed by DNA sequencing. A significant association was observed in the genotypic and allelic distribution of IL-6 -174 G/C in the NSCLC group as compared to control group [OR?=?2.7 (1.77–4.11), p?p?=?0.01), while 634C/G SNP showed an inverse relation [OR-0.4, p?IL-6 -174G/C genotype can be considered as one of the biological markers in the etiology of NSCLC. |
| Keywords: | Inflammation non-small cell lung cancer polymorphism restriction fragment length polymorphism (RFLP) |