Nasal in-situ gels for delivery of rasagiline mesylate: improvement in bioavailability and brain localization |
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| Authors: | P. R. Ravi N. Aditya S. Patil L. Cherian |
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| Affiliation: | 1. Pharmacy Department, BITS-Pilani Hyderabad Campus, Jawaharnagar, Andhra Pradesh, Indiarpunnarao@hyderabad.bits-pilani.ac.in rpunnarao@gmail.com;3. Pharmacy Department, BITS-Pilani Hyderabad Campus, Jawaharnagar, Andhra Pradesh, India |
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| Abstract: | AbstractIntranasal thermosensitive gel for rasagiline mesylate (RM) was developed for effective treatment of Parkinson’s disease. Intranasal gels were prepared by combination of poloxamer 407 and poloxamer 188 (1:1) with mucoadhesive polymers (carbopol 934?P and chitosan). The formulations were evaluated for sol–gel transition temperature, in-vitro drug release and in-vivo mucociliary transit time. Further, optimal intranasal gel formulations were tested for in-vivo pharmacokinetic behavior, nasal toxicity studies and brain uptake studies. It was found that optimal formulations had acceptable gelation temperature (28–33?°C) and adequate in-vitro drug release profile. Pharmacokinetic study in rabbits showed significant (p?p?
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| Keywords: | Bioavailability brain distribution intranasal gels pharmacokinetic studies rasagiline mesylate |
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