Polybutylcyanoacrylate nanocarriers as promising targeted drug delivery systems |
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| Authors: | Shiya Gao Yurui Xu Sajid Asghar Minglei Chen Lang Zou Sulieman Eltayeb |
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| Affiliation: | 1. Department of Pharmacy, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, People's Republic of China,;2. Department of Pharmacy, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, People's Republic of China,;3. Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan,;4. The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of China, and;5. Department of Pharmaceutics, Faculty of Pharmacy, Omdurman Islamic University, Omdurman, Sudan |
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| Abstract: | Among the materials for preparing the polymeric nanocarriers, poly(n-butylcyanoacrylate) (PBCA), a polymer with medium length alkyl side chain, is of lower toxicity and proper degradation time. Therefore, PBCA has recently been regarded as a kind of widely used, biocompatible, biodegradable, low-toxic drug carrier. This review highlights the use of PBCA-based nanocarriers (PBCA-NCs) as targeting drug delivery systems and presents the methods of preparation, the surface modification and the advantages and limitations of PBCA-NCs. The drugs loaded in PBCA-NCs are summarized according to the treatment of diseases, and the different therapeutic applications and the most recent developments of PBCA-NCs are also discussed, which provides useful guidance on the targeting research of PBCA-NCs. |
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| Keywords: | Pharmaceutical applications poly(butylcyanoacrylate) polymeric nanocarriers targeted drug delivery |
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