Correlation between oocyte morphology and the embryo aneuploidy rate in IVF cycles |
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| Authors: | Nataliya V. Dolgushina Anastasiia G. Syrkasheva Nataliya P. Makarova Eugenia V. Kovalskaya Elena A. Kalinina Gennady T. Sukhikh |
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| Affiliation: | 1. Federal State Budget Institution, The Research Center for Obstetrics, Gynecology and Perinatology (RCOGP), the Ministry of Health of the Russian Federation, Moscow, Russiandolgush@gmail.com n_dolgushina@oparina4.ru;3. Federal State Budget Institution, The Research Center for Obstetrics, Gynecology and Perinatology (RCOGP), the Ministry of Health of the Russian Federation, Moscow, Russia |
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| Abstract: | AbstractPurpose: To evaluate the aneuploidy rates of 13, 18, and 21 and the X and Y chromosomes in embryos from patients with morphologically normal oocytes and different oocyte dysmorphisms.Methods: This prospective cohort study included 84 patients treated with in vitro fertilization (IVF) at a single academic center. The patients were divided into the following three groups: group 1 – women with cytoplasmic dysmorphisms (n?=?28), group 2 – women with extracytoplasmic dysmorphisms (n?=?28), and group 3 – women with morphologically normal oocytes (n?=?28). One blastomere from each embryo was analyzed for aneuploidies of chromosomes 13, 18, 21, X, and Y.Results: The highest prevalence of aneuploid embryos was observed in the group 1 (68.4%) followed by the group 2 (38.9%) and the group 3 (31.3%) (р?Conclusions: Women with morphological oocyte abnormalities are at risk for developing aneuploid embryos during IVF cycles. We recommend that woman with cytoplasmic oocyte dysmorphisms receive additional genetic counseling to define the indications for the genetic screening of embryos. |
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| Keywords: | Aneuploidy in vitro fertilization oocyte dysmorphisms oocyte morphology oocyte quality preimplantation genetic screening |
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