系统性红斑狼疮患者医院感染的调查研究

目的：了解系统性红斑狼疮（SLE）的患者的医院感染情况。方法：对1995年3月至2002年3月新入院的456例SLE患者的医院感染进行调查。结果：SLE患者医院感染率为36．4％，呼吸道45．2％，泌尿道16．0％，皮肤12．6％，其他26．2％，以G－杆菌感染为主，致病菌对抗生素耐药率较高，结论：医院感染的易发因素是大量使用抗生素，激素及免疫抑制剂等。

A prospective study of nosocomial infection in patients with systemic lupus erythematosus

Objective To study the nosocomial infection in the patients with systemic lupus erythematosus (SLE). Methods A prospective survey of nosocomial infection in 456 cases with SLE was carried out for 84 months.Result Incidence of nosocomial infection in patients with SLE was 36 4%,infection of respiratory tract accounted for 45 2%,infection rates in urinary tract,skin and other regions were 16 0%,12 6% and 26 2% respectively.Gram negative bacilli were the predominant pathogens and the pathogens had higher frequency of multiple antibiotic resistance. Conclusion The factors related to nosocomial infection were the use of broadspectrum antibiotics,prednisone and administration of immunosuppressant,etc.