The influence of hepatic artery ligation and of vasopressin on liver tumour blood flow in rats. |
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Authors: | Peter Naredi Per Lindr Stig B Holmberg Rigmor Sderberg Gran Carlsson Bengt Gustavsson Lars Jacobsson Larsolof Hafstrm |
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Institution: | Department of Surgery, Sahlgrenska Hospital, University of G?teborg, Sweden. |
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Abstract: | The blood flow in an experimental adenocarcinoma in the rat liver was determined with the 133Xe-washout technique before and after hepatic artery ligation (HAL). There was an initial reduction of the washout of 50%. This was further reduced after 1 day by 50%, which was maintained for 7 days. Seven days after HAL or sham procedures the 133Xe-washout was of similar magnitude in the liver tumours, although after the sham procedure the tumours were larger (3.4 g vs. 1.5 g). The estimated tumour blood flow was then approximately 0.04 ml x min-1 x g-1. The influence on normal liver parenchyma of HAL was a reduction at 30 minutes, which was maintained for 7 days. Postacton--a synthetic vasopressin--did not influence the 133Xe-washout in normal liver parenchyma in non-tumour, as well as in tumour-bearing animals. There was no influence of Postacton on the 133Xe-washout in the liver tumours. Thirty minutes after HAL Postacton gave a reduction of blood flow in normal liver parenchyma of tumour-bearing animals, which is thus only from the portal vein. In tumours Postacton did not significantly reduce the tumour blood flow immediately after HAL. |
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Keywords: | hepatic artery occlusion 133Xe-washout vasopressin liver tumour |
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