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维生素C对S180移植腹水瘤荷瘤小鼠的影响
引用本文:丁红,张月明,陈冬梅,肖伟民,亚尔艾利,阿迪比叶提. 维生素C对S180移植腹水瘤荷瘤小鼠的影响[J]. 中国公共卫生, 2002, 18(8): 928-929
作者姓名:丁红  张月明  陈冬梅  肖伟民  亚尔艾利  阿迪比叶提
作者单位:新疆医科大学公共卫生学院,乌鲁木齐,830054
摘    要:目的:研究不同剂量维生素C对S180移植腹水瘤荷瘤小鼠一般状况及免疫水平的影响。方法:建立小鼠S180移植腹水瘤模型,维生素C干预7天后处死,测定小鼠血红蛋白含量,白细胞数目及体液免疫指标(血清溶血素)。细胞免疫指标(小鼠足跖肿胀实验)和脏/体重比值,结果:维生素C对荷瘤小鼠的血象改变有一定保护作用,对免疫脏器损伤有一定保护,但总体未见显性差异(P>0.05),维生素C对荷瘤小鼠的免疫功能具有显保护作用(P<0.01,P<0.05),且呈剂量依赖趋,结论:维生素C可提高荷瘤小鼠的免疫功能,并具有减轻荷瘤小鼠脏器受损程度及改善荷瘤小鼠血红蛋白含量的作用。

关 键 词:维生素C S180移植腹水瘤 荷瘤 小鼠 免疫功能
文章编号:1001-0580(2002)08-0928-02
修稿时间:2001-06-01

Study on Effects of Vitamin C on Mice Transplanted S180 Fluid Tumor
DING Hong,ZHANG Yue ming,CHEN Dong mei,et al.. Study on Effects of Vitamin C on Mice Transplanted S180 Fluid Tumor[J]. Chinese Journal of Public Health, 2002, 18(8): 928-929
Authors:DING Hong  ZHANG Yue ming  CHEN Dong mei  et al.
Affiliation:DING Hong,ZHANG Yue ming,CHEN Dong mei,et al.School of Public Health,Xinjiang Medical University
Abstract:Objective To study the effect of different dosages of vitamin C on the general condition and immunity level of mice transplanted S 180 fluid tumor.Methods The model for transplanted S 180 fluid tumor in mice was set up.The mice were given vitamin C for 7 days and then were killed.The amount of hemoglobin(Hb),the number of white blood cell(WBC),the index of humoral and cellular immunity,the ratio of weight of internal organs to that of mice body were determined.Results Vitamin C had the protective effect on the change of hemogram in tumor-bearing mice and on the damage of immunological organs.But there was not statistical difference.Vitamin C had the evidently protective effect on the immunological function of tumor-bearing mice by using statistical analysis and the degree of this effect depended on dosage.Conclusion Vitamin C can increase the immunological function of tumor-bearing mice,decrease the damage of internal organs in tumor-bearing mice,and can improve the amount of Hb.
Keywords:vitamin C  tumor-bearing mice  immunological function  
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