血清炎症因子在子痫前期病人发病中的作用机制及与氧化应激因子的相关性

目的探讨血清炎症因子和氧化应激因子在子痫前期病人发病中的作用及相关性。方法选取30例子痫前期孕产妇作为观察组，其中18例轻度子痫前期（轻度组），12例重度子痫前期（重度组），同时选取同期分娩的30例正常孕产妇作为对照组。比较不同组超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）与氧化低密度脂蛋白（ox-LDL）、丙二醛（MDA）及8-异构前列腺素（8-isoprostane）水平，分析子痫前期产妇hs-CRP、TNF-α、IL-6与ox-LDL、MDA及8-isoprostane的相关性。结果血清hs-CRP、TNF-α、IL-6炎症因子水平，血清ox-LDL、MDA、8-isoprostane氧化应激因子水平，子痫前期重度组产妇高于轻度组，轻度组高于对照组，差异均有统计学意义（P < 0.01）；子痫前期产妇血清ox-LDL、MDA、8-isoprostane等氧化应激因子与hs-CRP、TNF-α、IL-6等炎症因子水平具有正相关关系（P < 0.01）。结论血清炎症因子及氧化应激因子可能在子痫前期病人发病中具有重要作用，通过干预炎症和氧化应激反应有助于预防子痫前期疾病的发生和发展。

Action mechanism of serum inflammatory factors in the pathogenesis of preeclampsia and its correlation with oxidative stress factors

ObjectiveTo explore action mechanism of serum inflammatory factors and oxidative stress factors in the pathogenesis of preeclampsia and its correlation.MethodsThirty preeclampsia pregnant women were set as the observation group, which included 18 cases of mild preeclampsia(mild group) and 12 cases of severe preeclampsia(severe group).Meanwhile, 30 normal pregnant women with delivering at the same time were set as the control group.The serum levels of hs-CRP, TNF-α, IL-6 and ox-LDL, MDA and 8-isoprostane were compared among three groups, and the correlations of hs-CRP, TNF-α, IL-6 and ox-LDL and MDA with 8-isoprostane in preeclampsia pregnant women were analyzed.ResultsThe serum levels of inflammatory factors hs-CRP, TNF-α and IL-6, and serum levels of oxidative stress factors ox-LDL, MDA and 8-isoprostane in severe group were higher than those in mild group and control group, respectively(P < 0.01).The serum levels of ox-LDL, MDA and 8-isoprostane were positively correlated with the levels of hs-CRP, TNF-α and IL-6(P < 0.01).ConclusionsThe serum inflammatory and oxidative stress factors may play an important role in the pathogenesis of preeclampsia.Intervening the inflammation and oxidative stress response can help prevent the occurrence and development of preeclampsia.