荧光素钠辅助下高级别脑胶质瘤切除及预后临床效果分析

目的评价使用荧光素钠辅助下的高级别脑胶质瘤显微手术的肿瘤全切情况及患者预后临床效果。 方法回顾性纳入自2015年1月至2018年1月于厦门大学附属第一医院神经外科确诊的高级别脑胶质瘤患者85例，根据肿瘤切除术中是否使用荧光素钠辅助分别设为荧光素钠手术组（52例）和常规手术组（33例）。比较2组患者一般临床资料性别、患病年龄、侧别、肿瘤最大直径、囊实性情况、术前Karnofsky功能状态（KPS）评分]、术前术后KPS评分差、手术时长、术中出血量、术后并发症、肿瘤全切情况及无疾病进展生存时间（PFS）和总生存时间（OS）。 结果2组患者一般临床资料比较，差异均无统计学意义（P>0.05），具有可比性。2组患者术前术后KPS评分差及术中出血量比较差异无统计学意义（P>0.05），手术时长、术后并发症、肿瘤全切率、PFS和OS比较差异均具有统计学意义（P<0.05）。 结论使用荧光素钠辅助下的高级别胶质瘤显微手术可显著提高肿瘤全切率，缩短手术时长，延长患者PFS和OS，使高级别脑胶质瘤患者获益。

Analysis of the clinical effect of fluorescein sodium assisted resection and prognosis of high grade gliomas

ObjectiveTo evaluate the clinical effect of fluorescein sodium assisted microsurgery for high-grade gliomas. MethodsFrom January 2015 to January 2018, 85 patients with high-grade gliomas confirmed by Neurosurgery Department of the First Affiliated Hospital of Xiamen University were retrospectively enrolled. According to whether fluorescein sodium was used in tumor resection, they were divided into fluorescein sodium operation group (52 cases) and conventional operation group (33 cases). The general clinical data gender, age, side, maximum diameter of tumor, cystic and solid condition, preoperative Karnofsky performance status (KPS) score], KPS score was poor before and after operation, operation time, blood loss, postoperative complications, total tumor resection, progression free survival (PFS) and overall survival time (OS) were compared between the two groups. ResultsThere was no significant difference in general clinical data between the two groups (P>0.05). There was no significant difference in KPS score was poor before and after operation and intraoperative blood loss between the two groups (P>0.05). There were significant differences in operation time, postoperative complications, total tumor resection rate, PFS and OS between the two groups (P<0.05). Conclusionfluorescein sodium assisted microsurgery for high-grade gliomas can significantly improve the total tumor resection rate, shorten the operation time, prolong the PFS and OS time, and benefit the patients with high-grade glioma.