NT-proBNP与急性ST段抬高型心肌梗死患者SYNTAX评分的相关性研究

目的探讨NT-proBNP水平与急性ST段抬高型心肌梗（ST elevation myocardial infarction，STEMI）死患者SYNTAX积分（SS）的关系及意义。 方法回顾性分析2019年1月至2019年12月于中山大学附属第五医院心血管病中心诊断急性ST段抬高型心肌梗死（STEMI），并在发病后12 h内行急诊PCI治疗的105例患者的临床资料，计算每例患者的SYNTAX评分，根据得分情况将105例患者分为低分组、中分组、高分组，分析组间差异，并进一步评估NT-proBNP与SYNTAX评分之间的关系。 结果105例患者平均年龄55.10±11.67岁（29~84岁），其中男性患者92例，女性13例。根据SYNTAX得分情况分组，其中低分组18例，中分组38例，高分组49例。三组患者在基线水平比较上无统计学差异；但三组患者在左室射血分数（LVEF）、NT-proBNP、肌钙蛋白I、谷草转氨酶、乳酸脱氢酶、α-羟丁酸脱氢酶、肌酸激酶、肌酸激酶同工酶上存在显著显著统计学差异，P值均<0.05。相关性分析提示NT-proBNP与SYNTAX评分之间存在相关性，相关系数r=0.223，P=0.022。 结论对于行急诊PCI术治疗的STEMI患者，测定NT-proBNP水平可以提供除LVEF、SS评分之外评估心脏损伤程度及心脏功能的因素，可预测临床结局及指导远期治疗策略。

Correlation between NT-proBNP and SYNTAX score of STEMI patients

ObjectiveTo analyze the relationship between NT-proBNP and SYNTAX score of STEMI patients. MethodsThe clinical data of STEMI patients (n=105) admitted to the Fifth Affiliated Hospital of Sun Yat-sen University from January 2019 to December 2019 were retrospectively analyzed. The SYNTAX scores were calculated according to CAG results for 105 STEMI patients who underwent percutaneous coronary intervention (PCI). All patients were divided into three groups ccording to the SYNTAX score: low-SS group, mid-SS group and high-SS group, and the relationship between NT-proBNP and SYNTAX score were evaluated. ResultsThe average age of 105 STEMI patients (92 male and 13 female) was 55.10±11.67 years (range29-84years). According to the SYNTAX score, there were 18 cases in low-SS group, 38 cases in mid-SS group, and 49 cases in thigh-SS group. There was no significant difference in the baseline clinical characteristic between three groups. But there were significant differences in LVEF, NT-proBNP, cTnI, AST, LDH, α-HBD, CK, CK-MB between three groups (P<0.05). The results of Pearson correlation analysis showed that NT-proBNP was positively correlated to SYNTAX (r=0.223, P=0.022). ConclusionsThe level of NT-proBNP is tightly related to cardiac function and can be taken into consideration for decision-making among PCI in STEMI patients.