Caprini血栓风险评估量表预测人工肝治疗肝衰竭病人静脉血栓栓塞症风险有效性分析

目的了解Caprini血栓风险评估量表预测人工肝治疗肝衰竭病人静脉血栓栓塞症（VTE）风险的有效性。方法收集人工肝治疗肝衰竭病人100例，其中确诊为VTE病人25例作为观察组，非VTE病人75例作为对照组。回顾性收集病人临床资料包括病史、临床症状、治疗方案、实验室检查等，采用Caprini血栓风险评估量表分析2组病人Caprini风险评分、VTE危险度分级，多因素logistic回归模型分析人工肝治疗肝衰竭病人VTE危险度分级与VTE发病风险的关系。结果VTE组病人Caprini评分（4.280±1.948）高于对照组（2.947±2.155）（P < 0.01），危险度分级低于对照组（P < 0.05）。多因素logistic回归分析显示:年龄>60岁、卧床或制动>72 h、肥胖（BMI>25 kg/m2）、激素治疗、下肢水肿5个Caprini血栓风险评估量表中的危险因素是人工肝治疗肝衰竭病人发生VTE的主要高危风险因素（P < 0.05）。被评定为极高危人群发病风险是低危病人的8.667倍（P < 0.01）。结论Caprini血栓风险评估量表能较好地预测人工肝治疗肝衰竭病人发生VTE高危风险。

Validityan alysis of Caprini thrombosis assessment scale in assessing the risk of venous thromboembolism in liver failure patients treated with artificial liver

ObjectiveTo investigate the validity of the Caprini thrombosis assessment scale in predicting the risk of venous thromboembolism (VTE) in liver failure patients treated with artificial liver.MethodsOne hundred liver failure patients treated with artificial liver were divided into the VTE group (25 cases) and control group (75 cases without VTE).The clinical data (including medical history, clinical symptoms, treatment plan and laboratory examination) were retrospectively analyzed.The risk scale of Caprini and risk grading of VET were analyzed using the Caprini thrombosis risk assessment scale.The relationship between Caprini score and onset of VTE in liver failure patients treated with artificial liver were analyzed using multivariate logistic regression model.ResultsThe Caprini score in VTE group (4.280±1.948) was higher than that in control group (2.947±2.155) (P < 0.01), and the risk grading in VTE group was lower than that in control group (P < 0.05).The results of multivariate logistic regression analysis showed that the year > 60 years, bedridden or brake > 72 h, obesity (BMI>25 kg/m2), hormone therapy and lower extremity edema were the major high-risk factors of the onset of VTE in liver failure patients treated with artificial liver.The onset risk of VTE in the extremely high-risk patients was 8.667 times of that in low risk patients.ConclusionsThe Caprini thrombosis risk assessment scale is a good risk predictor for VTE in liver failure patients treated with artificial liver.