| 镁基合金生物可降解支架的国内外研究进展 |
| |
| 引用本文： | 孔令华,贺迎坤,李天晓,张一林,何艳艳,朱世杰,关绍康. 镁基合金生物可降解支架的国内外研究进展[J]. 中华介入放射学电子杂志, 2020, 8(1): 83-88. DOI: 10.3877/cma.j.issn.2095-5782.2020.01.016 |
| |
| 作者姓名： | 孔令华 贺迎坤 李天晓 张一林 何艳艳 朱世杰 关绍康 |
| |
| 作者单位： | 1. 450003 河南郑州，郑州大学人民医院介入中心脑血管病科、河南省人民医院、河南大学人民医院、河南省神经介入研发与应用工程研究中心2. 450003 河南郑州，郑州大学材料科学与工程学院 |
| |
| 基金项目： | 国家十三五重点研发计划(2016YFC1301700); 国家卫建委脑防委中国脑卒中高危人群干预和适宜技术研究及推广项目(GN-2016R0006，GN-2018R0007); 河南省科技攻关项目(162102310268); 河南省卫生科技攻关省部联合共建项目(SBGJ2018063); 河南省卫生健康科技英才海外研修工程项目(HWYX2019130); 河南大学一流学科培养项目(2019YLZDJL11) |
| |
| 摘 要： | 近年来，镁基合金生物可降解支架在血管领域的应用取得了很大进展。镁基合金作为一种生物降解材料，比铁基合金和锌基合金具有一定的优势。然而，镁基合金的降解速度太快，无法与组织愈合的速度相匹配，而且还表现出不均匀腐蚀的特性。因此，研究者们从支架的表面改性、锻造工艺和成分配比等方面优化支架生物金属特性，并且逐步运用到动物实验及临床研究。本综述主要围绕以下3个方面展开：镁基合金生物可降解支架的国内外发展历程；镁基合金生物可降解支架的特性；镁基合金生物可降解支架的研究热点。
|
| 关 键 词： | 生物可降解支架 镁基合金可降解支架 支架内再狭窄 支架内血栓 生物降解 |
| 收稿时间： | 2020-01-13 |
The Research progress of biodegradable magnesium alloy scaffolds at home and abroad |
| |
| Linghua Kong,Yingkun He,Tianxiao Li,Yilin Zhang,Yanyan He,Shijie Zhu,Shaokang Guan. The Research progress of biodegradable magnesium alloy scaffolds at home and abroad[J]. Chinese Journal of Interventional Radiology (Electronic Edition), 2020, 8(1): 83-88. DOI: 10.3877/cma.j.issn.2095-5782.2020.01.016 |
| |
| Authors: | Linghua Kong Yingkun He Tianxiao Li Yilin Zhang Yanyan He Shijie Zhu Shaokang Guan |
| |
| Affiliation: | 1. Department of Cerebrovascular Disease, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Provincial Neurointerventional Engineering Research Center, Henan Zhengzhou 450003, China2. School of Materials Science and Engineering, Zhengzhou University, Henan Zhengzhou, 450003, China |
| |
| Abstract: | In recent years, much progress has been made on the territory of biodegradable magnesium alloy scaffolds in Vascular system. As a biodegradable material, magnesium alloy scaffolds has certain advantages over iron base alloy and zinc base alloy. The degradation of magnesium is too rapid to match the rates of tissue healing and it exhibits the non-uniform corrosion mechanism.Therefore, researchers optimized the bimetallic properties of biodegradable magnesium alloy scaffolds from the surface modification, forging process and composition ratio. And scaffolds were applied to preclinical experiments and clinical research. This review focuses on the following topics: the development history at home and abroad and the characteristics of biodegradable magnesium alloy scaffolds. Furthermore, this review also covers research carried out in the field of development prospect of the stent. |
| |
| Keywords: | Bioresorbable scaffold Biodegradable magnesium alloy scaffold In-stent restenosis Biodegradation |
|
| 点击此处可从《中华介入放射学电子杂志》浏览原始摘要信息 |
|
点击此处可从《中华介入放射学电子杂志》下载全文 |
