高血压病人动态动脉硬化指数与血浆纤维蛋白原及D-二聚体的相关性研究

目的探讨高血压病人动态动脉硬化指数（AASI）与血浆纤维蛋白原（FIB）及D-二聚体（D-D）的关系。方法选取高血压病人220例，根据AASI中位数的大小分为A组（24h AASI < 0.52，n＝106）和B组（24h AASI≥0.52，n＝114）。比较各组间血FIB、D-D水平，并进行Pearson/Spearman相关分析与多元线性回归分析。结果A组的年龄、高血压病程、收缩压、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、FIB、D-D均低于B组（P < 0.05）。Pearson或Spearman相关性分析显示，高血压病人AASI与年龄（r=0.231，P < 0.05）、高血压病程（r=0.685，P < 0.05）、收缩压（r=0.721，P < 0.05）、血尿素氮（r=0.113，P < 0.05）、总胆固醇（r=0.628，P < 0.05）、LDL-C（r=0.666，P < 0.05）、FIB（r=0.887，P < 0.05）、D-D（r=0.668，P < 0.05）相关。多元线性回归分析显示，AASI与病程（β=0.107，P < 0.05）、收缩压（β=0.158，P < 0.05）、LDL-C（β=0.102，P < 0.05）、FIB（β=0.585，P < 0.05）、D-D（β=0.139，P < 0.05）相关。结论高血压病人AASI与血浆FIB及D-D相关，临床上通过药物干预血FIB及D-D的值可能延缓或控制动脉粥样硬化的进程。

Correlations of ambulatory arterial stiffness index with plasma fibrinogen and D-dimer in patients with hypertension

ObjectiveTo investigate the relationship between ambulatory arterial stiffness index(AASI)and plasma fibrinogen(FIB)and D-dimer(D-D)in patients with hypertension.MethodsAccording to the median value of AASI, 220 patients with hypertension were divided into group A(24 h AASI < 0.52, n=106)and group B(24 h AASI≥0.52, n=114).The levels of FIB and D-D were compared between the two groups.Pearson or Spearman correlation analysis and multiple linear regression analysis were performed.ResultsThe age, duration of hypertension, systolic blood pressure, total cholesterol, low density lipoprotein cholesterol(LDL-C), FIB and D-D in group A were lower than those in group B(P < 0.05).Pearson or Spearman correlation analysis showed that AASI in patients with hypertension was correlated with age(r=0.231, P < 0.05), duration of hypertension(r=0.685, P < 0.05), systolic blood pressure(r=0.721, P < 0.05), blood urea nitrogen(r=0.113, P < 0.05), total cholesterol(r=0.628, P < 0.05), LDL-C(r=0.666, P < 0.05), FIB(r=0.887, P < 0.05), and D-D(r=0.668, P < 0.05).Multiple linear regression analysis showed that AASI was correlated with duration of disease(β=0.107, P < 0.05), systolic blood pressure(β=0.158, P < 0.05), LDL-C(β=0.102, P < 0.05), FIB(β=0.585, P < 0.05), and D-D(β=0.139, P < 0.05).ConclusionsAASI in patients with hypertension is correlated with plasma FIB and D-D.Intervening the level of FIB and D-D by medicine may delay or control the progress of atherosclerosis.