Aging with HIV in the ART era |
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| Affiliation: | 1. Population, Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK;2. Beth Israel Deaconess Medical Center, Division of Infectious Diseases, Boston, MA, USA;3. Harvard TH Chan School of Public Health, Boston, MA, USA;4. Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana;1. Academic Model Providing Access to Healthcare, Eldoret, Kenya;2. Department of Pharmacy Practice, Temple University School of Pharmacy, Philadelphia, PA, USA;3. Department of HIV Medicine, Ian Charleson Day Centre, Royal Free Hospital, London, UK;4. Department of Clinical Pharmacy and Practice, Moi Teaching and Referral Hospital, Eldoret, Kenya;5. Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA;6. Divisions of Infectious Diseases and General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA;7. Center for Health Equity and Innovation, College of Pharmacy, Purdue University, Indianapolis, IN, USA |
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| Abstract: | In the current era of therapy for human immunodeficiency virus (HIV), life expectancy for persons living with HIV (PLWH) approaches that of the general population. This newly prolonged survival among PLWH is associated with an increased prevalence of comorbidities due to the inflammation, immune activation and immune senescence associated with HIV infection. Higher prevalence of tobacco and alcohol use, co-infection with viral hepatitis and traditional cardiovascular risk factors such as hypertension and hyperlipidemia contribute as well. In this review, we hope to describe the current comorbidities occurring among PLWH and bring increased awareness for conditions that may otherwise not be considered given the younger age at time of presentation. |
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| Keywords: | HIV Aging Accelerated aging Inflammation Inflammaging Multimorbidity Polypathology |
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