18F-FDG PET/CT在宫颈癌术后临床怀疑复发和转移病人中的应用价值

目的探讨18F-FDG PET/CT对宫颈癌术后临床怀疑复发和转移病人中的应用价值。方法收集临床怀疑宫颈癌术后复发及转移的女性病人56例。病人均进行18F-FDG PET/CT全身显像，应用半定量分析法和目测法判断结果。结果56例病人中，50例病人存在复发和/或转移，局部复发病灶的SUVmax从3.45至18.69，平均SUVmax为8.96。18F-FDG PET/CT诊断子宫颈癌术后复发及转移的灵敏度为98.0%，特异度为83.3%，诊断准确度为92.1%，阳性预测值为96.0%，阴性预测值为80.0%。CT分别为69.7%、78.9%、73.2%、86.7%、57.6%。两者各诊断效能指标比值比较，灵敏度、阴性预测值及诊断准确度有统计学意义（P < 0.05）。18F-FDG PET/CT显像诊断与组织病理或临床随访结果的一致性有统计学意义且有较高的一致性。结论18F-FDG PET/CT显像对于宫颈癌术后临床怀疑复发和转移有重要临床实用价值，为临床制定正确的治疗方案提供重要信息。

Application value of 18F-FDG PET/CT in patients with suspected recurrence and metastasis after cervical cancer surgery

ObjectiveTo investigate the application value of 18F-FDG PET/CT in patients with suspected recurrence and metastasis after cervical cancer surgery.MethodsThe clinical data of 56 female patients with suspected recurrence and metastasis of cervical cancer were collected.All patients were detected using 18F-FDG PET/CT whole-body imaging, and the results were determined by semi-quantitative analysis and visual examination.ResultsAmong 56 patients, the recurrence and/or metastasis in 50 patients were found.The SUVmax of local recurrence focus ranged from 3.45 to 18.69, with an average SUVmax of 8.96.The sensitivity, specificity, diagnostic accuracy, positive predictive value and negative predictive value of 18F-FDG PET/CT in the diagnosis of recurrence and metastasis of cervical cancer after operation were 98.0%, 83.3%, 92.1%, 96.0% and 80.0%, respectively.The sensitivity, specificity, diagnostic accuracy, positive predictive value and negative predictive value of CT were 69.7%, 78.9%, 73.2%, 86.7% and 57.6%, respectively.The differences of the sensitivity, negative predictive value and diagnostic accuracy between two methods were statistically significant (P < 0.05).The results of 18F-FDG PET/CT imaging diagnosis were consistent with the histopathological or clinical following-up results.ConclusionsThe 18F-FDG PET/CT imaging has important clinical practical value for suspected recurrence and metastasis of cervical cancer after operation, and can provide the important information for making correct treatment plan.