新型冠状病毒肺炎74例临床特性分析

目的 对新型冠状病毒肺炎确诊病人的临床特性进行分析并总结。 方法 回顾性分析蚌埠医学院第一附属医院2020年1月22日至3月4日收治的74例新型冠状病毒肺炎的临床特性，重点对比普通型及（危）重型病人临床特性的区别。 结果 74例病人中普通型35例，重型及危重型39例；家族聚集性发病的病人较多（37例，50.0%）；一般资料方面，（危）重型病人的年龄、合并其他基础性疾病率以及合并2种及2种以上基础疾病率均高于普通型病人（P < 0.05~P < 0.01）；临床症状方面，（危）重型病人发病至就诊的时间较普通型长，最高体温、胸闷发生率、呼吸困难发生率较普通型高（P < 0.05~P < 0.01）；实验室检查方面，（危）重型和普通型相比较，白细胞、中性粒细胞绝对值、中性粒细胞百分比、C反应蛋白以及白细胞介素-6较高，而淋巴细胞绝对值、淋巴细胞百分比和白蛋白较低（P < 0.05~P < 0.01）；胸部高分辨率CT检查均出现斑片状磨玻璃影。 结论 蚌埠地区病人聚集性病例较多；（危）重症病人以年龄偏大、合并基础病多、全身炎症反应大为特点。

Analysis of the clinical characteristics of 74 cases with Corona Virus Disease 2019

Objective To analyze the clinical characteristics of 74 patients with corona virus disease 2019(COVID-19). Methods The clinical characteristics of 74 pateints with COVID-19 from January 22 to March 4, 2020 from the First Affiliated Hospital of Bengbu Medical College were retrospectively analyzed, and the clinical characteristics were compared between common type and severe type patients. Results Among 74 patients, 35 cases were the common type, and 39 cases were severe/critical type cases.There were high number of familial cluster(37 cases, 50.0%).The age, and rates of complicated with other basic diseases and complicated with two or more basic diseases in severe/critical patients were higher than those in common patients(P < 0.05 to P < 0.01).In terms of clinical symptoms, the time from onset to see doctor in severe/critical patients was longer than that in common patients, and the highest body temperature, incidence rates of chest tightness and dyspnea in severe/critical patients were higher than those in common patients(P < 0.05 to P < 0.01).In terms of laboratory examination, the absolute value of leucocyte and neutrophil, percentage of neutrophil, C-reactive protein and interleukin-6 in severe/critical patients were higher compared with those in common patients, and the absolute value of lymphocyte, percentage of lymphocyte and albumin in severe/critical patients were lower compared with those in common patients(P < 0.05 to P < 0.01).The patchy ground glass opacity in chest CT of all cases were found. Conclusions The number of familial clustering cases of COVID-19 in Bengbu city is more, and the elderly complicated with more basic diseases and systemic inflammatory response are the clinical characteristics of severe/critical patients.