瑞戈非尼致不良反应的文献回顾性分析

目的：通过探讨瑞戈非尼不良反应发生的现状、规律、临床表现及转归，为临床医师安全用药提供参考依据。方法：检索2013-2018年国际学术期刊有关瑞戈非尼不良反应的个案报道，采用回顾性研究方法，对患者基本情况、疾病信息、不良反应临床表现及转归等多方面进行统计分析。结果：共纳入文献37篇，涉及不良反应共43例，其中新的不良反应12例；患者中男性24例（55.81%），女性19例（44.19%），男女比例为1：0.79，发生的平均年龄为（61.07±10.04）岁；瑞戈非尼引起的ADRs主要发生在1个月之内（75%）；其所致ADRs以消化系统（33.77%）为主，皮肤及附件损害的ADRs其次（25.97%）。结论：瑞戈非尼引起的不良反应可累及全身多个系统，临床医师和药师应了解瑞戈非尼致ADRs的规律和特点，加强用药监测，以减少不良反应的发生。

Literature review analysis of adverse drug reactions induced by regorafenib

OBJECTIVE To explore the current situation,pattern,clinical manifestation and prognosis of adverse reactions of regorafenib,in order to provide a reference for clinicians to use drugs safely.METHODS Case reports of regorafenib ADRs which were published in international medical academic journals during 2013-2018 were retrieved.The retrospective study method was used to statistically analyze the basic situation,disease information,clinical manifestations and outcome of adverse reactions.RESULTS A total of 37 literatures were included,involving 43 cases,among which there were 12 cases of new ADR.24 cases (55.81%) were males and 19 cases (44.19%) were females,with a male to female ratio of 1:0.79 and a mean age of (61.07±10.04) years;.Most adverse reactions occured with in one month (n=30,75%) after therapy.Lesions of digestive system was the most commonly reported ADRs (33.77%),followed by the lesions of skin and its appendants (25.97%).CONCLUSION The adverse reactions induced by regorafenib may involve multiple systems.Clinicians and pharmacists should be aware of the regularity and characteristics of regorafenib-induced ADRs,and strengthen drug monitoring to reduce adverse reactions.