HCV感染与肾移植后糖尿病关系的荟萃分析

目的应用荟萃分析系统评价HCV感染是否为肾移植后糖尿病(PTDM)的相关危险因素。 方法系统检索中国期刊全文数据库、中国生物医学数据库、PubMed数据库、Embase数据库、Google scholar和Web of science database截至2019年12月公开发表的相关文献。应用Stata 15.1统计软件使用随机效应模型进行荟萃分析，计算相对危险度(RR)。 结果共纳入22篇文献，包含129 981例肾移植受者。荟萃分析结果显示，HCV感染的肾移植受者术后发生PTDM的风险为非HCV感染者的2.5倍(RR＝2.50, 95%CI: 1.95～3.20, P<0.001)。在亚洲、高加索和美洲人种中，HCV感染均为肾移植术后PTDM的危险因素。 结论HCV感染是促进肾移植术后发生PTDM的危险因素，感染者需尽早进行清除HCV的相关治疗。

Relationship between hepatitis C virus infection and post transplantation diabetes mellitus: a meta-analysis

ObjectiveTo use a meta-analysis system to evaluate whether hepatitis C virus (HCV) infection is a risk factor for post transplantation diabetes mellitus (PTDM) in kidney transplant recipients. MethodsAll the papers published up to December 2019 in Chinese journal full-text database, Chinese biomedical database, PubMed database, Embase database, Google scholar and Web of science database had been systematically searched. A meta-analysis was performed using a random effects model using Stata 15.1 software to calculate relative risk (RR). ResultsA total of 22 articles including 129 981 kidney transplant recipients were included. The results of meta-analysis showed that HCV infected recipients did have an relative risk of PTDM by about 2.5 times to non HCV infected recipients (RR=2.50, 95%CI: 1.95-3.20, P<0.001). Subgroup analysis based on race found that HCV infection was a significant risk factor for PTDM after kidney transplantation in Asian, Caucasian, and American races. ConclusionsHCV infection is a risk factor that promotes PTDM in recipients after kidney transplantation. Infected recipients should be treated as soon as possible to elimate HCV.