原发性胆汁性胆管炎心脑血管事件发生风险的Meta分析

目的 通过Meta分析系统评价原发性胆汁性胆管炎(PBC)人群心脑血管事件风险,以期提供最新的高级别循证医学证据。方法 计算机检索国内外公开发表的PBC并发心脑血管事件风险的文献,提取心脑血管事件风险效应量并通过RevMan 5.3软件进行Meta分析。结果 与对照组相比,PBC组冠脉事件风险显著增高(RR=1.56;P=0.0002),脑血管事件风险差异无统计学意义(RR=1.01,P=0.94);进一步亚组分析显示,PBC组短暂性脑缺血发作或颈动脉狭窄风险显著低于对照组(RR=0.63,P=0.03),而卒中风险差异无统计学意义(RR=1.11,P=0.40)。结论 PBC人群有可能并发更高的冠心病风险,而发生早期脑血管事件如短暂性脑缺血发作或颈动脉狭窄等风险更低。

Meta Analysis of Risks of Cardiocerebral Vascular Events in Patients with Primary Biliary Cholangitis

Objective To systematically evaluate the risks of cardiocerebral vascular events in patients with primary biliary cholangitis(PBC). Methods We carried out a Meta analysis by RevMan 5.3 software to investigate literatureon the risk of cardiocerebral vascular events in patients with PBC and controls. Results Compared with non-PBC controls,PBC patients had significantly higher risk of coronary events(RR=1.56,P=0.0002);however,the risk of cerebrovascular events showed no significant difference between these two groups(RR=1.01,P=0.94).Subgroup analysis demonstrated a significantly lower risk of transient ischemic attack or carotid stenosis in PBC patients(RR=0.63,P=0.03);however,there was no significant difference in the risk of stroke(RR=1.11,P=0.40). Conclusion Patients with PBC have an increased risk of coronary events but may have a lower risk of transient ischemic attack or carotid stenosis.