PRNCR1在前列腺癌诊断及预后的价值

目的 探讨前列腺癌非编码RNA1（PRNCR1）在前列腺癌早期诊断及预后的价值。方法 选取2012年1月至2015年10月在本院诊治前列腺癌患者45例、良性前列腺增生患者88例，进行PRNCR1检验。结果 PRNCR1 检验的灵敏度84.4%（38/45）、特异度90.9%（80/88）、阳性预测值82.6%（38/46）、阴性预测值92.0%（80/87)、符合率88.7%（118/133），PRNCR1在前列腺癌组织中含量高于癌旁组织和良性前列腺增生组织，差异有统计学意义（P<0.05）。两年内转移、复发、肿瘤死亡患者30例，其PRNCRA表达量高于两年内无转移、复发、死亡的患者（15例），差异有统计学意义（P<0.05）。结论 PRNCR1表达在诊断前列腺癌有价值，PRNCR1高表达与患者预后不良有关。

The value of PRNCR1 in the diagnosis and prognosis of prostate cancer

Objective   To analyze the value of PRNCR1 in the early diagnosis and prognosis of prostate cancer.Methods   From January 2012 to October 2015, the prostate cancer (n=45) and benign prostatic hyperplasia (n=88) tissues of surgical group were enrolled into PRNCR1 group and RNA test.Results  The sensitivity of the 84.4%(38/45) PRNCR1 RNA test, specificity 90.9%(80/88), positive predictive value 82.6%(38/46), and negative predictive value of 92% (80/87), the coincidence rate was 88.7%(118/133), PRNCR1 in prostate cancer was higher than that of adjacent tissues and benign prostatic hyperplasia tissues, the difference was statistically significant (P<0.05). Within 2 years, tumor recurrence and metastasis object of 30 death cases of PRNCR1 cells was higher than that of 2 years without recurrence, metastasis, the object of 15 death cases, the difference was statistically significant(P<0.05). Conclusions  The expression of PRNCR1 is valuable in the diagnosis of prostate cancer, and the high expression of PRNCR1 is associated with poor prognosis.