上转换荧光纳米颗粒NaYF 4: Yb,Er的二氧化硅包覆及活性官能团修饰

目的对上转换纳米颗粒进行表面修饰，以利于生物应用。 方法利用热分解法合成NaYF₄: Yb, Er粒子，然后采用微乳液法在粒子表面包覆一薄层SiO₂，并在其表面修饰环氧基团，采用透射电子显微镜、荧光光谱仪和傅里叶红外光谱分析仪分别对颗粒形貌、发光特性和表面性能进行表征。 结果采用热分解法合成了大小均一，六方相的NaYF₄: Yb, Er颗粒，二氧化硅包覆纳米粒子后仍具有较强的发光特性，并进一步成功修饰上了环氧基团。 结论上转换纳米粒子经过表面修饰后具有较强的发光特性和稳定性，可作为生物荧光标记物应用于生物医学领域。

Reactive functional groups decorate fluoride upconversion nanoparticles NaYF 4: Yb,Er with silica coating

ObjectiveTo modify the surface of nanoparticles for biological application. MethodsNaYF₄: Yb, Er nanoparticles were synthesized by thermal decomposition method, then a thin layer of SiO₂ was coated on the surface of above nanoparticles by microemulsion method and epoxy group was also modified on the surface. In addition, the nanoparticles morphology, luminescence properties and surface properties were characterized by transmission electron microscopy (TEM), fluorescence spectroscopy and fourier infrared spectrum analyzer(FT-IR),respectively. ResultsUniform-size and hexagonal-phase NaYF₄: Yb, Er were synthesized by thermal decomposition method. Silica-coated NaYF₄: Yb, Er nanoparticles still had strong luminescence properties, and nanoparticles could be further modified with epoxide group. ConclusionThe fluoride upconversion nanoparticle with strong luminescence properties and stability after surface modification could be used as a new biological fluorescent marker in the biomedical field.