| 外泌体在类风湿性关节炎发病机制中的研究进展 |
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| 引用本文： | 邓雷弘,龚芸,黄晓林,巢海潮. 外泌体在类风湿性关节炎发病机制中的研究进展[J]. 中国医学科学院学报, 2019, 41(4): 556-561. DOI: 10.3881/j.issn.1000-503X.10648 |
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| 作者姓名： | 邓雷弘 龚芸 黄晓林 巢海潮 |
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| 作者单位： | 1.南昌大学研究生院医学部,南昌 3300062 浙江大学医学院附属邵逸夫医院内分泌科,杭州 3100003 贵州医科大学口腔医学,贵阳 5500044 江西省人民医院临床医学研究所,南昌 330006 |
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| 基金项目： | 江西省科技厅青年科学基金(20171BAB215015) |
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| 摘 要： | 外泌体是细胞主动分泌的一种直径30~100 nm的囊泡状小体,其内容物含有蛋白质、脂质及RNA等多种成分。外泌体参与介导细胞间的通讯,参与炎症反应、细胞增殖与分化、组织修复、免疫信号通路转导及应激反应等体内多种生理及病理进程。大量研究显示外泌体可以调节、维持自身免疫性疾病,尤其是类风湿性关节炎的发生与进展,其可能是类风湿性关节炎新的诊断标志物及潜在的治疗载体。
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| 关 键 词： | 外泌体 自身免疫性疾病 类风湿性关节炎 |
| 收稿时间： | 2018-06-22 |
Exosomes in the Pathogenesis of Rheumatoid Arthritis |
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| DENG Leihong,GONG Yun,HUANG Xiaolin,CHAO Haichao. Exosomes in the Pathogenesis of Rheumatoid Arthritis[J]. Acta Academiae Medicinae Sinicae, 2019, 41(4): 556-561. DOI: 10.3881/j.issn.1000-503X.10648 |
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| Authors: | DENG Leihong GONG Yun HUANG Xiaolin CHAO Haichao |
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| Affiliation: | 1.Department of Medicine,Graduate School,Nanchang University,Nanchang 330006,China2 Department of Endocrinology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China3 Department of Stomatology,School of Guizhou Medical University,Guiyang 550004,China4 Institute of Clinical Medicine,Jiangxi Province People’s Hospital,Nanchang 330006,China; |
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| Abstract: | Exosomes are 30-100 nm vesicles secreted from almost all types of cells.They contain various molecular constituents,including proteins,lipids,and RNA.As important mediators of cell-to-cell communication,exosomes are involved in a variety of physiological and pathological processes such as inflammatory reaction,cell proliferation and differentiation,tissue repair,immune signal transduction,and stress response.Exosomes can regulate and maintain the initiation and progression of many autoimmune diseases,especially rheumatoid arthritis.Meanwhile,exosomes may be a new biomarker for the diagnosis of rheumatoid arthritis and a potential treatment vector for this disease. |
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| Keywords: | exosomes autoimmune disease rheumatoid arthritis |
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