超声引导下经皮射频消融治疗黏膜下子宫肌瘤的有效性和安全性

 目的 探讨超声引导下经皮射频消融治疗黏膜下子宫肌瘤的有效性和安全性。方法 回顾性分析2016-03至2017-11收治的78例有症状的黏膜下子宫肌瘤,计算子宫肌瘤的完全消融率并评价治疗结果,比较术后3个月子宫肌瘤体积、血红蛋白(Hb)定量及子宫肌瘤症状及健康相关生活质量问卷(UFS-QOL)评分。观察和记录治疗过程中及治疗后随访期间患者出现的各种不良反应及并发症。结果 射频消融后3、6、9、12个月病灶体积缩小率分别为65.3%、75.6%、81.5%和91.6%。治疗3个月后,体积减少(35.1±9.7)cm³,血红蛋白增加(31.9±44.05 )g/L,UFS-QOL评分中SSS评分减少(24.7±13.2),HRQL评分增加(17.3±18.65),差异均有统计学意义(P＜0.01)。术后3 d检查未发现严重并发症。结论 超声引导下经皮射频消融治疗黏膜下子宫肌瘤是一种安全有效的治疗方法,适合对子宫保留有需求的患者。

Clinical value of ultrasound-guided radiofrequency ablation for submucous uterine fibroids

Objective To investigate the efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for submucous uterine fibroids. Methods A retrospective study of 78 patients with symptomatic submucosal uterine fibroids who were treated between March 2016 and November 2017 and met the inclusion criteria was performed to calculate the complete ablation rate of uterine fibroids. The results were compared and the uterus was compared 3 months after ablation,so were fibroid volume, hemoglobin (Hb) quantification, uterine fibroid symptoms and health-related quality of life questionnaire (UFS-QOL) scores. Adverse reactions and complications were recorded during the course of treatment and follow-up.Results The volume reduction rates of lesions at 3, 6, 9, and 12 months after radiofrequency ablation were 65.3%, 75.6%, 81.5%, and 91.6%, respectively. The volume of uterine fibroids, hemoglobin and UFS-QOL scores were significantly decreased at 3 months after treatment (P<0.01). No serious complications were found three days after ablation.Conclusions Ultrasound-guided percutaneous radiofrequency ablation is a safe and effective treatment for submucosal uterine fibroids,which is suitable for patients with uterus retention.